Simon H Friedman1. 1. Division of Pharmacology and Pharmaceutical Sciences, University of Missouri-Kansas City, School of Pharmacy, 2464 Charlotte Street, Kansas City, MO, 64108, USA. Friedmans@umkc.edu.
Abstract
PURPOSE OF REVIEW: The aim of this review is to summarize the development of the photoactivated depot (PAD) approach for the minimally invasive and continuously variable delivery of insulin. RECENT FINDINGS: Using an insulin PAD, we have demonstrated that we can release native, bioactive insulin into diabetic animals in response to light signals from a small external LED light source. We have further shown that this released insulin retains bioactivity and reduces blood glucose. In addition, we have designed and constructed second generation materials that have high insulin densities, with the potential for multiple day delivery. The PAD approach for insulin therapy holds promise for addressing the pressing need for continuously variable delivery methods that do not rely on pumps, and their myriad associated problems.
PURPOSE OF REVIEW: The aim of this review is to summarize the development of the photoactivated depot (PAD) approach for the minimally invasive and continuously variable delivery of insulin. RECENT FINDINGS: Using an insulin PAD, we have demonstrated that we can release native, bioactive insulin into diabetic animals in response to light signals from a small external LED light source. We have further shown that this released insulin retains bioactivity and reduces blood glucose. In addition, we have designed and constructed second generation materials that have high insulin densities, with the potential for multiple day delivery. The PAD approach for insulin therapy holds promise for addressing the pressing need for continuously variable delivery methods that do not rely on pumps, and their myriad associated problems.
Authors: Lutz Heinemann; G Alexander Fleming; John R Petrie; Reinhard W Holl; Richard M Bergenstal; Anne L Peters Journal: Diabetologia Date: 2015-03-18 Impact factor: 10.122
Authors: Zhen Gu; Alex A Aimetti; Qun Wang; Tram T Dang; Yunlong Zhang; Omid Veiseh; Hao Cheng; Robert S Langer; Daniel G Anderson Journal: ACS Nano Date: 2013-05-02 Impact factor: 15.881