Literature DB >> 31696169

The construction of DNAzyme-based logic gates for amplified microRNA detection and cancer recognition.

Lingyu Wu1, Min Pan, Yuqi Chen, Haiyan Huang, Xiaoe Zhang, Fuan Wang, Xiang Zhou.   

Abstract

Benefiting from the simple DNAzyme and a duplex-specific nuclease, a series of microRNA-stimulated DNAzyme logic gates were rationally assembled for the highly accurate detection of multiple low-abundant microRNA biomarkers that correspond to the specific aberrant microRNA expression patterns of cancer tissues, thus showing a great potential in early diagnosis.

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Year:  2019        PMID: 31696169     DOI: 10.1039/c9an01977d

Source DB:  PubMed          Journal:  Analyst        ISSN: 0003-2654            Impact factor:   4.616


  2 in total

1.  Constructing Controllable Logic Circuits Based on DNAzyme Activity.

Authors:  Fengjie Yang; Yuan Liu; Bin Wang; Changjun Zhou; Qiang Zhang
Journal:  Molecules       Date:  2019-11-15       Impact factor: 4.411

2.  DNA Matrix Operation Based on the Mechanism of the DNAzyme Binding to Auxiliary Strands to Cleave the Substrate.

Authors:  Shaoxia Xu; Yuan Liu; Shihua Zhou; Qiang Zhang; Nikola K Kasabov
Journal:  Biomolecules       Date:  2021-11-30
  2 in total

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