| Literature DB >> 31693880 |
Tatiana Kisseleva1, David A Brenner2.
Abstract
Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key components of the xCT-glutamate→mGluR5-2-AG→CB1R-SREBP1-FASN paracrine communication system, Choi et al. identified potential new targets for drugs for ALD.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31693880 DOI： 10.1016/j.cmet.2019.10.010
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287