Literature DB >> 31692781

CD13 regulation of membrane recycling: implications for cancer dissemination.

Mallika Ghosh1, Linda H Shapiro1.   

Abstract

Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif containing, guanosine triphosphate hydrolase activating protein 1 (IQGAP1) scaffolding protein at the plasma membrane, thus stimulating the recycling regulator ADP-ribosylation factor 6 (ARF6) to ensure proper recycling of β1-integrin and other membrane components impacting cell attachment.
© 2019 Taylor & Francis Group, LLC.

Entities:  

Keywords:  CD13; anpep; endocytosis; membrane recycling

Year:  2019        PMID： 31692781      PMCID： PMC6816439          DOI： 10.1080/23723556.2019.1648024

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again.

Authors:  Donna J Webb; J Thomas Parsons; Alan F Horwitz
Journal:  Nat Cell Biol       Date:  2002-04       Impact factor: 28.824

Review 2.  Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Authors:  Neil O Carragher; Margaret C Frame
Journal:  Trends Cell Biol       Date:  2004-05       Impact factor: 20.808

3.  Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.

Authors:  Jaganathan Subramani; Mallika Ghosh; M Mamunur Rahman; Leslie A Caromile; Claire Gerber; Karim Rezaul; David K Han; Linda H Shapiro
Journal:  J Immunol       Date:  2013-08-30       Impact factor: 5.422

4.  Integrin-mediated adhesion regulates membrane order.

Authors:  Katharina Gaus; Soazig Le Lay; Nagaraj Balasubramanian; Martin A Schwartz
Journal:  J Cell Biol       Date:  2006-08-28       Impact factor: 10.539

5.  CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration.

Authors:  Mallika Ghosh; Robin Lo; Ivan Ivic; Brian Aguilera; Veneta Qendro; Charan Devarakonda; Linda H Shapiro
Journal:  Sci Signal       Date:  2019-04-30       Impact factor: 8.192

6.  CD13 restricts TLR4 endocytic signal transduction in inflammation.

Authors:  Mallika Ghosh; Jaganathan Subramani; M Mamunur Rahman; Linda H Shapiro
Journal:  J Immunol       Date:  2015-03-23       Impact factor: 5.422

7.  CD13/APN regulates endothelial invasion and filopodia formation.

Authors:  Nenad Petrovic; Wolfgang Schacke; J Reed Gahagan; Catherine A O'Conor; Beata Winnicka; Rebecca E Conway; Paola Mina-Osorio; Linda H Shapiro
Journal:  Blood       Date:  2007-03-15       Impact factor: 22.113

Review 8.  Integrin traffic - the update.

Authors:  Nicola De Franceschi; Hellyeh Hamidi; Jonna Alanko; Pranshu Sahgal; Johanna Ivaska
Journal:  J Cell Sci       Date:  2015-02-06       Impact factor: 5.285

9.  CD13 is a novel mediator of monocytic/endothelial cell adhesion.

Authors:  Paola Mina-Osorio; Beata Winnicka; Catherine O'Conor; Christina L Grant; Lotte K Vogel; Daniel Rodriguez-Pinto; Kathryn V Holmes; Enrique Ortega; Linda H Shapiro
Journal:  J Leukoc Biol       Date:  2008-05-21       Impact factor: 4.962

10.  Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.

Authors:  Archana Pawar; Jeremy A Meier; Anwesha Dasgupta; Neha Diwanji; Neha Deshpande; Kritika Saxena; Natasha Buwa; Siddhi Inchanalkar; Martin Alexander Schwartz; Nagaraj Balasubramanian
Journal:  Cell Signal       Date:  2016-06-04       Impact factor: 4.315
  10 in total

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