Literature DB >> 31692008

The CCL20 and CCR6 axis in psoriasis.

Kazuhisa Furue1, Takamichi Ito1, Gaku Tsuji2, Takeshi Nakahara3, Masutaka Furue1,2,3.   

Abstract

Psoriasis is a TNF-α/IL-23/IL-17A-mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A-producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A-rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.
© 2019 The Scandinavian Foundation for Immunology.

Entities:  

Keywords:  CCL20; CCR6; Koebner phenomenon; Th17; psoriasis

Mesh：

Substances：

Year:  2019        PMID： 31692008     DOI： 10.1111/sji.12846

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  19 in total

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