Literature DB >> 31691360

Isatin-azole hybrids and their anticancer activities.

Yani Hou1, Congshan Shang1, Hui Wang1, Jie Yun1.   

Abstract

Isatin and azole moieties, which have the ability to form various noncovalent interactions with different therapeutic targets, are common pharmacophores in drug development. Isatin and azole derivatives possess promising in vitro and in vivo anticancer activity, and many of them, such as semaxanib, sunitinib, and carboxyamidotriazole, could be used to treat various cancers. Thus, it is conceivable that hybridization of the isatin moiety with azole may provide a valuable therapeutic intervention for the treatment of cancer. Substantial efforts have been made to develop isatin-azole hybrids as novel anticancer agents, and some of the isatin-azole hybrids exhibited considerable activity. This review emphasizes isatin-azole hybrids with potential anticancer activity, covering articles published between 2010 and 2019. The structure-activity relationships as well as the mechanisms of action are also discussed to provide insights for the rational design of more effective candidates.
© 2019 Deutsche Pharmazeutische Gesellschaft.

Entities:  

Keywords:  anticancer; azole; hybrid molecules; isatin; mechanism; structure-activity relationship

Mesh：

Substances：

Year:  2019        PMID： 31691360     DOI： 10.1002/ardp.201900272

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  10 in total

1.  Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways.

Authors:  Nagwa G Tawfik; Wafaa R Mohamed; Hanan S Mahmoud; Mohammed A Alqarni; Ibrahim A Naguib; Alzhraa M Fahmy; Osama M Ahmed
Journal:  Antioxidants (Basel)       Date:  2022-04-01

2.  Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors.

Authors:  Tarfah Al-Warhi; Ahmed M El Kerdawy; Nada Aljaeed; Omnia E Ismael; Rezk R Ayyad; Wagdy M Eldehna; Hatem A Abdel-Aziz; Ghada H Al-Ansary
Journal:  Molecules       Date:  2020-04-27       Impact factor: 4.411

3.  The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.

Authors:  Yinghui Shang; Qinghai Wang; Jian Li; Qiangqiang Zhao; Xueyuan Huang; Hang Dong; Haiting Liu; Ye Zhang; Junhua Zhang; Rong Gui; Xinmin Nie
Journal:  Onco Targets Ther       Date:  2020-01-15       Impact factor: 4.147

4.  Design, Synthesis and Anti-Lung Cancer Evaluation of 1, 2, 3-Triazole Tethered Dihydroartemisinin-Isatin Hybrids.

Authors:  Haodong Hou; Bin Qu; Chen Su; Guihua Hou; Feng Gao
Journal:  Front Pharmacol       Date:  2021-12-16       Impact factor: 5.810

5.  Three-Carbon Linked Dihydroartemisinin-Isatin Hybrids: Design, Synthesis and Their Antiproliferative Anticancer Activity.

Authors:  Min Dong; Guili Zheng; Feng Gao; Min Li; Chen Zhong
Journal:  Front Pharmacol       Date:  2022-01-26       Impact factor: 5.810

6.  The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines.

Authors:  Mansoor-Ali Vaali-Mohammed; Maha-Hamadien Abdulla; Sabine Matou-Nasri; Wagdy M Eldehna; M Meeramaideen; Eslam B Elkaeed; Mohammed El-Watidy; Noura S Alhassan; Khayal Alkhaya; Omar Al Obeed
Journal:  Front Pharmacol       Date:  2022-08-15       Impact factor: 5.988

7.  Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases.

Authors:  Mohamed Mokhtar; Khadijah S Alghamdi; Nesreen S Ahmed; Dina Bakhotmah; Tamer S Saleh
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

8.  Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer.

Authors:  Wagdy M Eldehna; Rofaida Salem; Zainab M Elsayed; Tarfah Al-Warhi; Hamada R Knany; Rezk R Ayyad; Thamer Bin Traiki; Maha-Hamadien Abdulla; Rehan Ahmad; Hatem A Abdel-Aziz; Radwan El-Haggar
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

9.  A Neuroprotective Dose of Isatin Causes Multilevel Changes Involving the Brain Proteome: Prospects for Further Research.

Authors:  Alexei Medvedev; Arthur Kopylov; Olga Buneeva; Leonid Kurbatov; Olga Tikhonova; Alexis Ivanov; Victor Zgoda
Journal:  Int J Mol Sci       Date:  2020-06-11       Impact factor: 5.923

10.  5-Aryl-1-Arylideneamino-1H-Imidazole-2(3H)-Thiones: Synthesis and In Vitro Anticancer Evaluation.

Authors:  Ali H Abu Almaaty; Eslam E M Toson; El-Sherbiny H El-Sayed; Mohamed A M Tantawy; Eman Fayad; Ola A Abu Ali; Islam Zaki
Journal:  Molecules       Date:  2021-03-18       Impact factor: 4.411
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.