MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake.

Effects of the enantiomers of MDL 72832, a novel, potent and selective ligand for 5-HT1A sites, were investigated in a test of platable food consumption in partially pre-satiated male rats. (-)-MDL 72832 significantly increased feeding at 0.03 mg/kg s.c., whereas 1.0 mg/kg (+)-MDL 72832 was required to stimulate food intake. The stereospecificity of the effect provides support for a functional role of 5-HT1A receptors in feeding responses.