Nicola Veronese1,2, Brendon Stubbs3, Sarah E Jackson4, Ai Koyanagi5, Vania Noventa6, Francesco Bolzetta7, Alberto Cester7, Pinar Soysal8, Stefania Maggi1,2, Guillermo F López-Sánchez9, Mike Loosemore10, Jacopo Demurtas11, Lee Smith12. 1. Aging Branch, Neuroscience Institute, National Research Council, Padova, Italy. 2. Department of Geriatric Care, Orthogeriatrics and Rehabilitation, E. O. Galliera Hospital, National Relevance & High Specialization Hospital, Genoa, Italy. 3. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Box, SE5 8AF, London, UK. 4. Department of Behavioural Science and Health, University College London, London, UK. 5. Research and Development Unit, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Parc Sanitari Sant Joan de Déu, Carrer Del Dr. Antoni Pujadas 42, Barcelona, Spain. 6. Primary Care Department, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", 30031, Dolo, Mirano District, Italy. 7. Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", 30031, Dolo, Mirano District, Italy. 8. Department of geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. 9. Faculty of Sport Sciences, University of Murcia, Murcia, Spain. 10. Institute of Sport Exercise and Health Sciences, University College London Hospital, London, UK. 11. Primary Care Department, Azienda USL Toscana Sud Est, 58100, Grosseto, Italy. 12. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK. lee.smith@anglia.ac.uk.
Abstract
BACKGROUND: Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal. AIMS: This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample. METHODS: This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements. RESULTS: The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006). CONCLUSION: In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.
BACKGROUND: Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal. AIMS: This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample. METHODS: This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements. RESULTS: The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006). CONCLUSION: In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.
Entities:
Keywords:
Cardiovascular disease; Chair stand time; Gait Speed; Osteoarthritis; WOMAC
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