Kamil Litwinowicz1, Marcin Choroszy2, Ewa Waszczuk3. 1. Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland. 2. Department of Microbiology, Wroclaw Medical University, Wroclaw, Poland. 3. Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland.
Abstract
Background: A growing body of evidence highlights the role of the intestine in the development of various alcohol use disorder (AUD) complications. The intestinal microbiome has been proposed as an essential factor in mediating the development of AUD complications such as alcoholic liver disease. Objectives: To provide a comprehensive description of alcohol-induced intestinal microbiome alterations. Methods: We conducted a systematic review of studies investigating the effect of alcohol on the intestinal microbiome using the PRISMA checklist. We searched the Medline database on the PubMed platform for studies determining the effect of alcohol on microbiota in individuals with AUD. The manual search included references of retrieved articles. Only human studies examining the intestinal bacterial microbiome using 16S ribosomal RNA sequencing were included. Data comparing relative abundances of bacteria comprising intestinal microbiota was extracted. Results: We retrieved 17 studies investigating intestinal microbiome alterations in individuals with AUD. Intestinal microbiome alterations in individuals with AUD included depletion of Akkermansia muciniphila and Faecalibacterium prausnitzii and an increase of Enterobacteriaceae. At the phylum level, a higher abundance of Proteobacteria and lower of Bacteroidetes were found. Mixed results regarding Bifidobacterium were obtained. Several species of short-chain fatty acids producing bacteria had a lower abundance in individuals with alcohol use disorder. Conclusion: Intestinal microbiome alterations associated with dysbiosis in individuals with AUD are generally consistent across studies, making it a promising target in potential AUD complications treatment.
Background: A growing body of evidence highlights the role of the intestine in the development of various alcohol use disorder (AUD) complications. The intestinal microbiome has been proposed as an essential factor in mediating the development of AUD complications such as alcoholic liver disease. Objectives: To provide a comprehensive description of alcohol-induced intestinal microbiome alterations. Methods: We conducted a systematic review of studies investigating the effect of alcohol on the intestinal microbiome using the PRISMA checklist. We searched the Medline database on the PubMed platform for studies determining the effect of alcohol on microbiota in individuals with AUD. The manual search included references of retrieved articles. Only human studies examining the intestinal bacterial microbiome using 16S ribosomal RNA sequencing were included. Data comparing relative abundances of bacteria comprising intestinal microbiota was extracted. Results: We retrieved 17 studies investigating intestinal microbiome alterations in individuals with AUD. Intestinal microbiome alterations in individuals with AUD included depletion of Akkermansia muciniphila and Faecalibacterium prausnitzii and an increase of Enterobacteriaceae. At the phylum level, a higher abundance of Proteobacteria and lower of Bacteroidetes were found. Mixed results regarding Bifidobacterium were obtained. Several species of short-chain fatty acids producing bacteria had a lower abundance in individuals with alcohol use disorder. Conclusion: Intestinal microbiome alterations associated with dysbiosis in individuals with AUD are generally consistent across studies, making it a promising target in potential AUD complications treatment.
Authors: Alicia Rodríguez-González; Francesco Vitali; Marta Moya; Carlotta De Filippo; Maria Beatrice Passani; Laura Orio Journal: Front Cell Infect Microbiol Date: 2021-11-23 Impact factor: 5.293
Authors: Ricardo Wesley Alberca; Paula Ordonhez Rigato; Yasmim Álefe Leuzzi Ramos; Franciane Mouradian Emidio Teixeira; Anna Cláudia Calvielli Branco; Iara Grigoletto Fernandes; Anna Julia Pietrobon; Alberto Jose da Silva Duarte; Valeria Aoki; Raquel Leão Orfali; Maria Notomi Sato Journal: Front Nutr Date: 2021-06-02