OBJECTIVE: The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS: Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Multivariable regression models were used to determine factors independently associated with abdominal pain at follow-up. RESULTS: Response rate was 71% (110/155). Of respondents, median age was 51 years, 58% were female, and 14% had severe AP. At follow-up, 24% of patients reported abdominal pain (65% intermittent, 35% constant), 10% used analgesics regularly, and 6% had regular opioids use. Furthermore, 41% of patients experienced pain-related interference with work or daily activities, and 8% developed disability. On regression analysis, idiopathic etiology (odds ratio [OR], 3.8; 95% confidence interval [CI], 1.1-13.6) persistent organ failure (OR, 3.3; 95% CI, 1.1-7.9), and recurrent AP (OR, 2.9; 95% CI, 1.1-10.6) were independently associated with abdominal pain at follow-up. Disability at follow-up was associated with younger age, current smoking, and intensive care unit admission (all P < 0.05). CONCLUSIONS: Abdominal pain and disability are potential long-term sequelae of AP. Certain pre-existing factors and pancreatitis features are associated with these outcomes at one-year follow-up of AP.
OBJECTIVE: The aim of the study was to report the prevalence and predictors of abdominal pain and disability 1 year after an acute pancreatitis (AP) attack. METHODS:Patients were prospectively enrolled between December 2012 and April 2016. Enrolled subjects were contacted at a median of 13 months after enrollment. Multivariable regression models were used to determine factors independently associated with abdominal pain at follow-up. RESULTS: Response rate was 71% (110/155). Of respondents, median age was 51 years, 58% were female, and 14% had severe AP. At follow-up, 24% of patients reported abdominal pain (65% intermittent, 35% constant), 10% used analgesics regularly, and 6% had regular opioids use. Furthermore, 41% of patients experienced pain-related interference with work or daily activities, and 8% developed disability. On regression analysis, idiopathic etiology (odds ratio [OR], 3.8; 95% confidence interval [CI], 1.1-13.6) persistent organ failure (OR, 3.3; 95% CI, 1.1-7.9), and recurrent AP (OR, 2.9; 95% CI, 1.1-10.6) were independently associated with abdominal pain at follow-up. Disability at follow-up was associated with younger age, current smoking, and intensive care unit admission (all P < 0.05). CONCLUSIONS:Abdominal pain and disability are potential long-term sequelae of AP. Certain pre-existing factors and pancreatitis features are associated with these outcomes at one-year follow-up of AP.
Authors: David C Whitcomb; Tooru Shimosegawa; Suresh T Chari; Christopher E Forsmark; Luca Frulloni; Pramod Garg; Peter Hegyi; Yoshiki Hirooka; Atsushi Irisawa; Takuya Ishikawa; Shuiji Isaji; Markus M Lerch; Philippe Levy; Atsushi Masamune; Charles M Wilcox; John Windsor; Dhiraj Yadav; Andrea Sheel; John P Neoptolemos Journal: Pancreatology Date: 2018-05-21 Impact factor: 3.996
Authors: Chandraprakash Umapathy; Amit Raina; Shreyas Saligram; Gong Tang; Georgios I Papachristou; Mordechai Rabinovitz; Jennifer Chennat; Herbert Zeh; Amer H Zureikat; Melissa E Hogg; Kenneth K Lee; Melissa I Saul; David C Whitcomb; Adam Slivka; Dhiraj Yadav Journal: J Gastrointest Surg Date: 2016-09-12 Impact factor: 3.452
Authors: Peter A Banks; Thomas L Bollen; Christos Dervenis; Hein G Gooszen; Colin D Johnson; Michael G Sarr; Gregory G Tsiotos; Santhi Swaroop Vege Journal: Gut Date: 2012-10-25 Impact factor: 23.059
Authors: Stephanie L M Das; Primal P Singh; Anthony R J Phillips; Rinki Murphy; John A Windsor; Maxim S Petrov Journal: Gut Date: 2013-08-08 Impact factor: 23.059
Authors: Pedram Paragomi; Anna Evans Phillips; Jorge D Machicado; Ali Lahooti; Ayesha Kamal; Elham Afghani; Ioannis Pothoulakis; Shari L Reynolds; Melanie Mays; Darwin L Conwell; Luis F Lara; Vikesh K Singh; Georgios I Papachristou Journal: Pancreas Date: 2021-02-01 Impact factor: 3.243