Leo Nicolai1,2, Steffen Massberg1,2. 1. Medizinische Klinik und Poliklinik I, Klinikum der Ludwig-Maximilians-Universität. 2. DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Abstract
PURPOSE OF REVIEW: This review highlights recent insights into the role of platelets in acute inflammation and infection. RECENT FINDINGS: Platelets exhibit intravascular crawling behavior and can collect and bundle bacteria. In addition, platelets are key in promoting intravascular thrombus formation in infection, a process termed 'immunothrombosis', which contributes to pathogen containment, but also potentially damages the host. Platelets are at the nexus of leukocyte recruitment and activation, yet they are at the same time crucial in preventing inflammation-associated hemorrhage and tissue damage. This multitasking requires specific receptors and pathways, depending on stimulus, organ and effector function. SUMMARY: New findings highlight the complex interplay of innate immunity, coagulation and platelets in inflammation and infection, and unravel novel molecular pathways and effector functions. These offer new potential therapeutic approaches, but require further extensive research to distinguish treatable proinflammatory from host-protective pathways.
PURPOSE OF REVIEW: This review highlights recent insights into the role of platelets in acute inflammation and infection. RECENT FINDINGS: Platelets exhibit intravascular crawling behavior and can collect and bundle bacteria. In addition, platelets are key in promoting intravascular thrombus formation in infection, a process termed 'immunothrombosis', which contributes to pathogen containment, but also potentially damages the host. Platelets are at the nexus of leukocyte recruitment and activation, yet they are at the same time crucial in preventing inflammation-associated hemorrhage and tissue damage. This multitasking requires specific receptors and pathways, depending on stimulus, organ and effector function. SUMMARY: New findings highlight the complex interplay of innate immunity, coagulation and platelets in inflammation and infection, and unravel novel molecular pathways and effector functions. These offer new potential therapeutic approaches, but require further extensive research to distinguish treatable proinflammatory from host-protective pathways.
Authors: Yu N Avtaeva; I S Mel'nikov; O S Saburova; K G Guriya; M C Osidak; C P Domogatsky; Z A Gabbasov Journal: Bull Exp Biol Med Date: 2021-10-07 Impact factor: 0.804
Authors: Mai M Aly; Taghreed S Meshref; Marwa A Abdelhameid; Shimaa A Ahmed; Asmaa S Shaltout; Alaa Eldin Abdel-Moniem; Dina A Hamad Journal: J Blood Med Date: 2021-06-29