Literature DB >> 31687431

Statistical modelling of data showing pandemic H1N1 2009 swine influenza a virus infection kinetics in vaccinated pigs.

Laetitia Canini1, Helen E Everett2, Mario Aramouni3, Vivien Coward2, Andrew Ramsay2, Michael Kelly2, Sophie Morgan4, Elma Tchilian4, Sarah Gilbert3, Bryan Charleston4, Ian H Brown2, Sharon M Brookes2, Mark E J Woolhouse1.   

Abstract

A swine influenza A pandemic 2009 H1N1 (pH1N1) virus was used in a pig challenge model to investigate the efficacy of whole inactivated vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. Nasal shedding of viral RNA was monitored daily by real-time, quantitative RT-PCR (RRT-qPCR) as detailed (1). Here we report the statistical modelling of the viral RNA shedding kinetics. Crown
Copyright © 2019 Published by Elsevier Inc.

Entities:  

Keywords:  Pandemic 2009 swine influenza a virus; Statistical modelling RRT-qPCR; Viral kinetics; Whole inactivated vaccine

Year:  2019        PMID： 31687431      PMCID： PMC6820103          DOI： 10.1016/j.dib.2019.104576

Source DB:  PubMed          Journal:  Data Brief        ISSN： 2352-3409


  2 in total

1.  Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus.

Authors:  Helen E Everett; Mario Aramouni; Vivien Coward; Andrew Ramsay; Michael Kelly; Sophie Morgan; Elma Tchilian; Laetitia Canini; Mark E J Woolhouse; Sarah Gilbert; Bryan Charleston; Ian H Brown; Sharon M Brookes
Journal:  Vaccine       Date:  2019-03-23       Impact factor: 3.641

2.  Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach.

Authors:  Cédric Laouénan; Jeremie Guedj; France Mentré
Journal:  BMC Med Res Methodol       Date:  2013-04-25       Impact factor: 4.615
  2 in total

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