| Literature DB >> 31686349 |
Yosuke Matsumoto1, Yoshiaki Chinen2,3, Yuji Shimura3, Hisao Nagoshi4, Nana Sasaki5, Ayako Muramatsu6, Kodai Kuriyama6, Muneo Ohshiro6, Yoshiko Hirakawa6, Toshiki Iwai6, Hitoji Uchiyama6, Tomohiko Taki7,8, Shigeo Horiike3, Junya Kuroda3, Masafumi Taniwaki8.
Abstract
Expression of intragenic exon rearrangements (IERs) has reportedly been detected in both normal and cancer cells. However, there have been few reports of occurrence of these rearrangements specific to neoplasms including malignant lymphoma. In this study, we detected IERs of ten genes (NBPF8, SOBP, AUTS2, RAB21, SPATA13, ABCC4, WDR7, PHLPP1, NFATC1 and MAGED1) in non-Hodgkin B cell lymphoma (B-NHL) cell line KPUM-UH1 using a high-resolution single nucleotide polymorphism array and reverse transcription polymerase chain reaction using reversely directed divergent primers within exons involved in genomic intragenic gains followed by sequencing analysis. Among them, the IERs involved in SOBP (6q21) exon 2 and 3 and AUTS2 (7q11.22) exon 2-4 were the molecular lesions specific to tumors and were frequently detected in B-NHL samples. These IERs constitute novel genetic alterations of B-NHL, which might be associated with tumorigenesis and be useful as genetic biological markers.Entities:
Keywords: AUTS2; Intragenic exon rearrangement; Lymphoma; SOBP
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Year: 2019 PMID： 31686349 DOI： 10.1007/s12185-019-02766-z
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490