| Literature DB >> 31686093 |
D Michelson1, M Grundman, K Magnuson, R Fisher, J M Levenson, P Aisen, K Marek, M Gray, F Hefti.
Abstract
The engineered fusion protein NPT088 targets amyloid in vitro and in animal models of Alzheimer's disease. Previous studies showed that NPT088 treatment reduced β-amyloid plaque and tau aggregate loads in mouse disease models. Here, we present the results from an initial clinical study of NPT088 in patients with mild to moderate Alzheimer's disease. Patients were treated with 4 dose levels of NPT088 for 6 months to evaluate its safety and tolerability. Exploratory measurements included measurement of change in β-amyloid plaque and tau burden utilizing Positron Emission Tomography imaging as well as measures of Alzheimer's disease symptoms. At endpoint NPT088 was generally safe and well-tolerated with the most prominent finding being infusion reactions in a minority of patients. No effect of NPT088 on brain plaques, tau aggregates or Alzheimer's disease symptoms was observed.Entities:
Keywords: Alzheimer’s disease; Amyloid; tau tangles; β-amyloid plaques
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Year: 2019 PMID： 31686093 DOI： 10.14283/jpad.2019.37
Source DB: PubMed Journal: J Prev Alzheimers Dis ISSN： 2274-5807