BACKGROUND: Non-secretory multiple myeloma (NSMM) is a rare subtype of multiple myeloma (MM) characterized by the absence of monoclonal protein in the serum and/or urine. We look at the clinical and cytogenetic features of NSMM in this study. PATIENTS AND METHODS: This study evaluates a cohort of 30 patients with newly diagnosed NSMM seen at the Mayo Clinic, Rochester, MN, between 2008 and 2018 and treated with novel agent induction therapies. Survival outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test. RESULTS: These patients with NSMM appear to have a large disease burden at diagnosis with a median bone marrow plasma cell percentage of 70% and more than one-half of all patients having Multiple Myeloma International Staging System Stage III disease. There was a higher preponderance for t(11;14) primary cytogenetic abnormality in this NSMM cohort, accounting for more than 50% of the cohort. Finally, the overall survival of this cohort appears to be slightly worse than a matched-control group of newly diagnosed patients with MM with secretory disease. CONCLUSIONS: Future multi-institution studies confirming these above findings on this rare entity are warranted.
BACKGROUND: Non-secretory multiple myeloma (NSMM) is a rare subtype of multiple myeloma (MM) characterized by the absence of monoclonal protein in the serum and/or urine. We look at the clinical and cytogenetic features of NSMM in this study. PATIENTS AND METHODS: This study evaluates a cohort of 30 patients with newly diagnosed NSMM seen at the Mayo Clinic, Rochester, MN, between 2008 and 2018 and treated with novel agent induction therapies. Survival outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test. RESULTS: These patients with NSMM appear to have a large disease burden at diagnosis with a median bone marrow plasma cell percentage of 70% and more than one-half of all patients having Multiple Myeloma International Staging System Stage III disease. There was a higher preponderance for t(11;14) primary cytogenetic abnormality in this NSMM cohort, accounting for more than 50% of the cohort. Finally, the overall survival of this cohort appears to be slightly worse than a matched-control group of newly diagnosed patients with MM with secretory disease. CONCLUSIONS: Future multi-institution studies confirming these above findings on this rare entity are warranted.
Authors: E Terpos; J F Apperley; D Samson; C Giles; C Crawley; E Kanfer; E Olavarria; J M Goldman; A Rahemtulla Journal: Bone Marrow Transplant Date: 2003-02 Impact factor: 5.483
Authors: Philippe Moreau; Asher Chanan-Khan; Andrew W Roberts; Amit B Agarwal; Thierry Facon; Shaji Kumar; Cyrille Touzeau; Elizabeth A Punnoose; Jaclyn Cordero; Wijith Munasinghe; Jia Jia; Ahmed Hamed Salem; Kevin J Freise; Joel D Leverson; Sari Heitner Enschede; Jeremy A Ross; Paulo C Maciag; Maria Verdugo; Simon J Harrison Journal: Blood Date: 2017-08-28 Impact factor: 22.113
Authors: Daniel Coriu; Kristal Weaver; Maria Schell; Manfred Eulitz; Charles L Murphy; Deborah T Weiss; Alan Solomon Journal: Blood Date: 2004-04-15 Impact factor: 22.113
Authors: Shaji K Kumar; S Vincent Rajkumar; Angela Dispenzieri; Martha Q Lacy; Suzanne R Hayman; Francis K Buadi; Steven R Zeldenrust; David Dingli; Stephen J Russell; John A Lust; Philip R Greipp; Robert A Kyle; Morie A Gertz Journal: Blood Date: 2007-11-01 Impact factor: 22.113
Authors: Shaji Kumar; Jonathan L Kaufman; Cristina Gasparetto; Joseph Mikhael; Ravi Vij; Brigitte Pegourie; Lofti Benboubker; Thierry Facon; Martine Amiot; Philippe Moreau; Elizabeth A Punnoose; Stefanie Alzate; Martin Dunbar; Tu Xu; Suresh K Agarwal; Sari Heitner Enschede; Joel D Leverson; Jeremy A Ross; Paulo C Maciag; Maria Verdugo; Cyrille Touzeau Journal: Blood Date: 2017-10-10 Impact factor: 22.113