Joyce S Xiao1, Martin Healey2, Alon Talmor3, Beverley Vollenhoven4. 1. Monash University, Clayton Victoria, Australia. 2. Monash IVF, 252 Clayton Road, Clayton, Victoria, Australia; Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia. 3. Department of Obstetrics & Gynaecology, Monash University, Clayton, Victoria, Australia; Womens and Newborn Programme, Monash Health, 246 Clayton Road, Clayton, Victoria, Australia; Monash IVF, 252 Clayton Road, Clayton, Victoria, Australia; Epworth Richmond, 89 Bridge Road, Richmond 3121, Australia. 4. Department of Obstetrics & Gynaecology, Monash University, Clayton, Victoria, Australia; Womens and Newborn Programme, Monash Health, 246 Clayton Road, Clayton, Victoria, Australia; Monash IVF, 252 Clayton Road, Clayton, Victoria, Australia. Electronic address: ollenhoven@monash.edu.
Abstract
RESEARCH QUESTION: In patients with only one embryo on Day 3 post-IVF treatment, does transferring the embryo into the uterine environment achieve a higher pregnancy rate than growing the embryo on with a plan to transfer at Day 4-6? DESIGN: This was a retrospective cohort study conducted in patients with only one viable embryo on Day 3 post-IVF treatment. Data were extracted from a standardized IVF database and included 1384 women who fulfilled this study's selection criteria. Outcomes of these embryos were followed up and stratified into two groups: embryos transferred on Day 3 and those grown on to Day 4-6. Pregnancy rate (biochemical and clinical) and live birth rates were analysed with logistic regression and adjusted using a parsimonious model for baseline patient characteristics. RESULTS: Biochemical pregnancy (16.7% versus 9.5%, odds ratio [OR] 1.9, P = 0.001), clinical pregnancy (14.7% versus 6.8%, OR 2.35, P < 0.001) and live birth rates (9.7% versus 4.4%, OR 2.37, P = 0.002) were significantly higher in the Day 3 group than those in the group grown on to Day 4-6. These differences were still significant after adjusting for potential confounders (adjusted OR 2.60, 3.71, 4.08, respectively, P < 0.001). CONCLUSIONS: These findings support Day 3 cleavage-stage embryo transfer instead of growing on to Day 4-6 for blastocyst-stage transfer when only a single embryo is available.
RESEARCH QUESTION: In patients with only one embryo on Day 3 post-IVF treatment, does transferring the embryo into the uterine environment achieve a higher pregnancy rate than growing the embryo on with a plan to transfer at Day 4-6? DESIGN: This was a retrospective cohort study conducted in patients with only one viable embryo on Day 3 post-IVF treatment. Data were extracted from a standardized IVF database and included 1384 women who fulfilled this study's selection criteria. Outcomes of these embryos were followed up and stratified into two groups: embryos transferred on Day 3 and those grown on to Day 4-6. Pregnancy rate (biochemical and clinical) and live birth rates were analysed with logistic regression and adjusted using a parsimonious model for baseline patient characteristics. RESULTS: Biochemical pregnancy (16.7% versus 9.5%, odds ratio [OR] 1.9, P = 0.001), clinical pregnancy (14.7% versus 6.8%, OR 2.35, P < 0.001) and live birth rates (9.7% versus 4.4%, OR 2.37, P = 0.002) were significantly higher in the Day 3 group than those in the group grown on to Day 4-6. These differences were still significant after adjusting for potential confounders (adjusted OR 2.60, 3.71, 4.08, respectively, P < 0.001). CONCLUSIONS: These findings support Day 3 cleavage-stage embryo transfer instead of growing on to Day 4-6 for blastocyst-stage transfer when only a single embryo is available.
Authors: Inge Van Vaerenbergh; Tom Adriaenssens; Wim Coucke; Lisbet Van Landuyt; Greta Verheyen; Michaël De Brucker; Michel Camus; Peter Platteau; Michel De Vos; Elien Van Hecke; André Rosenthal; Johan Smitz Journal: Reprod Biol Endocrinol Date: 2021-02-19 Impact factor: 5.211
Authors: Michael F Neblett; Tana Kim; Tiffanny L Jones; Sarah C Baumgarten; Charles C Coddington; Yulian Zhao; Chandra C Shenoy Journal: F S Rep Date: 2021-06-29