Henry H Cheng1, Silvina L Ferradal2, Rutvi Vyas2, Daniel Wigmore1, Erica McDavitt1, Janet S Soul3, Mari A Franceschini4, Jane W Newburger1, P Ellen Grant5. 1. Department of Cardiology, Boston Children's Hospital, Boston, Mass. 2. Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, Mass. 3. Department of Neurology, Boston Children's Hospital, Boston, Mass. 4. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Mass. 5. Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, Mass. Electronic address: Ellen.Grant@childrens.harvard.edu.
Abstract
OBJECTIVE: To use novel optical techniques to measure perioperative cerebral hemodynamics of diverse congenital heart disease (CHD) groups (two-ventricle, d-transposition of the great arteries [TGA], and single ventricle [SV]) and (1) compare CHD groups with healthy controls preoperatively and (2) compare preoperative and postoperative values within each CHD group. METHODS: Frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy were used to measure cerebral oxygen saturation, cerebral blood volume, cerebral blood flow index, cerebral oxygen extraction fraction (OEF, calculated using arterial oxygen saturation and cerebral oxygen saturation), and an index of cerebral metabolic rate of oxygen consumption in control and CHD neonates. Preoperative CHD measures were compared with controls. Preoperative and postoperative measures were compared within each CHD group. RESULTS: In total, 31 CHD neonates (7 two-ventricle, 11 TGA, 13 SV) and 13 controls were included. Only neonates with SV CHD displayed significantly lower preoperative cerebral blood flow index (P < .04) than controls. TGA and SV groups displayed greater OEF (P < .05) during the preoperative period compared with controls. Compared with the preoperative state, postoperative neonates with TGA had a greater arterial oxygen saturation with lower OEF. CONCLUSIONS: Differences in cerebral hemodynamics and oxygen metabolism were observed in diverse CHD groups compared with controls. Increased OEF appears to be a compensatory mechanism in neonates with TGA and SV. Studies are needed to understand the relationship of these metrics to outcome and their potential to guide interventions to improve outcome.
OBJECTIVE: To use novel optical techniques to measure perioperative cerebral hemodynamics of diverse congenital heart disease (CHD) groups (two-ventricle, d-transposition of the great arteries [TGA], and single ventricle [SV]) and (1) compare CHD groups with healthy controls preoperatively and (2) compare preoperative and postoperative values within each CHD group. METHODS: Frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy were used to measure cerebral oxygen saturation, cerebral blood volume, cerebral blood flow index, cerebral oxygen extraction fraction (OEF, calculated using arterial oxygen saturation and cerebral oxygen saturation), and an index of cerebral metabolic rate of oxygen consumption in control and CHD neonates. Preoperative CHD measures were compared with controls. Preoperative and postoperative measures were compared within each CHD group. RESULTS: In total, 31 CHD neonates (7 two-ventricle, 11 TGA, 13 SV) and 13 controls were included. Only neonates with SV CHD displayed significantly lower preoperative cerebral blood flow index (P < .04) than controls. TGA and SV groups displayed greater OEF (P < .05) during the preoperative period compared with controls. Compared with the preoperative state, postoperative neonates with TGA had a greater arterial oxygen saturation with lower OEF. CONCLUSIONS: Differences in cerebral hemodynamics and oxygen metabolism were observed in diverse CHD groups compared with controls. Increased OEF appears to be a compensatory mechanism in neonates with TGA and SV. Studies are needed to understand the relationship of these metrics to outcome and their potential to guide interventions to improve outcome.
Authors: Erin M Buckley; Dalton Hance; Thomas Pawlowski; Jennifer Lynch; Felice B Wilson; Rickson C Mesquita; Turgut Durduran; Laura K Diaz; Mary E Putt; Daniel J Licht; Mark A Fogel; Arjun G Yodh Journal: J Biomed Opt Date: 2012-03 Impact factor: 3.170
Authors: Mathieu Dehaes; Henry H Cheng; Erin M Buckley; Pei-Yi Lin; Silvina Ferradal; Kathryn Williams; Rutvi Vyas; Katherine Hagan; Daniel Wigmore; Erica McDavitt; Janet S Soul; Maria Angela Franceschini; Jane W Newburger; P Ellen Grant Journal: Biomed Opt Express Date: 2015-11-09 Impact factor: 3.732
Authors: Jennifer M Lynch; Tiffany Ko; David R Busch; John J Newland; Madeline E Winters; Kobina Mensah-Brown; Timothy W Boorady; Rui Xiao; Susan C Nicolson; Lisa M Montenegro; J William Gaynor; Thomas L Spray; Arjun G Yodh; Maryam Y Naim; Daniel J Licht Journal: J Thorac Cardiovasc Surg Date: 2018-05-03 Impact factor: 5.209
Authors: Chao Zhou; Stephanie A Eucker; Turgut Durduran; Guoqiang Yu; Jill Ralston; Stuart H Friess; Rebecca N Ichord; Susan S Margulies; Arjun G Yodh Journal: J Biomed Opt Date: 2009 May-Jun Impact factor: 3.170
Authors: Daniel J Licht; Jiongjiong Wang; David W Silvestre; Susan C Nicolson; Lisa M Montenegro; Gil Wernovsky; Sarah Tabbutt; Suzanne M Durning; David M Shera; J William Gaynor; Thomas L Spray; Robert R Clancy; Robert A Zimmerman; John A Detre Journal: J Thorac Cardiovasc Surg Date: 2004-12 Impact factor: 5.209
Authors: David Wypij; Richard A Jonas; David C Bellinger; Pedro J Del Nido; John E Mayer; Emile A Bacha; Joseph M Forbess; Frank Pigula; Peter C Laussen; Jane W Newburger Journal: J Thorac Cardiovasc Surg Date: 2008-02 Impact factor: 5.209
Authors: Kaitlyn Easson; Guillaume Gilbert; Charles V Rohlicek; Christine Saint-Martin; Maxime Descoteaux; Sean C L Deoni; Marie Brossard-Racine Journal: Hum Brain Mapp Date: 2022-04-12 Impact factor: 5.399