Literature DB >> 3168442

Inhibition of pregnancy before and after implantation in rats with monoclonal antibody against progesterone.

A Phillips1, D W Hahn, J McGuire, M W Wang, R B Heap, V Rider, M J Taussig.   

Abstract

A monoclonal antibody against progesterone completely blocked pregnancy when rats were injected intraperitoneally at 0.53 mumol/kg/day on days 1 and 2, or on day 11 of a first pregnancy. The antibody was equally effective when injected again during a second pregnancy. There was no evidence for anti-idiotypic antibody production even when the injection of a heterologous (mouse) antibody was repeated in a second pregnancy.

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Year:  1988        PMID： 3168442     DOI： 10.1016/0010-7824(88)90100-x

Source DB:  PubMed          Journal:  Contraception        ISSN： 0010-7824            Impact factor:   3.375


  2 in total

1.  Blocking of pregnancy in mice by immunization with anti-idiotype directed against monoclonal anti-progesterone antibody.

Authors:  M W Wang; R B Heap; M J Taussig
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

2.  Induction of anti-progesterone immunity and pregnancy blocking by anti-progesterone anti-idiotypes. Variable efficacy of polyclonal Ab2 antibodies directed against a panel of closely related Ab1 antibodies.

Authors:  M W Wang; M J Sims; P R Symington; A S Humphreys; M J Taussig
Journal:  Immunology       Date:  1991-07       Impact factor: 7.397
  2 in total

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