Justyna Miszczyk1, Kamila Rawojć2, Agnieszka Panek3, Aleksander Gałaś4, Aldona Kowalska5, Artur Szczodry6, Kamil Brudecki7. 1. Department of Experimental Physics of Complex Systems, Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland. Electronic address: justyna.miszczyk@ifj.edu.pl. 2. Department of Endocrinology, Nuclear Medicine Unit, The University Hospital, Kraków, Poland. 3. Department of Experimental Physics of Complex Systems, Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland. 4. Chair of Epidemiology and Preventive Medicine, Department of Epidemiology, Jagiellonian University Medical College, Kraków, Poland. 5. Department of Endocrinology and Nuclear Medicine, Holy Cross Cancer Center, Kielce, Poland; The Faculty of Health Sciences, The Jan Kochanowski University, Kielce, Poland. 6. Department of Endocrinology and Nuclear Medicine, Holy Cross Cancer Center, Kielce, Poland. 7. Department of Nuclear Physical Chemistry, Institute of Nuclear Physics Polish Academy of Sciences, Kraków, Poland.
Abstract
PURPOSE: To physically and cytogenetically screen medical personnel of Department of Endocrinology and Nuclear Medicine, Holy Cross Cancer Center, Kielce, Poland (DENM) who are occupationally exposed to 131I. MATERIALS AND METHODS: The exposure was monitored by whole-body and finger ring dosimeters. The thyroid iodine intake was measured by a whole-body spectrometer equipped with two semiconductor gamma radiation detectors. A cytokinesis-block micronucleus assay and the premature chromosome condensation technique were used to assess the aberration score. Cytogenetic analyses were carried out on a group of 29 workers and were compared to 32 controls (healthy donors), matched for gender and age. RESULTS: On average, the exposed group showed a significantly higher frequency of genetic damage and a higher proliferation index compared to the control group. Smoking status, age and duration of exposure influenced the observed effects in both groups. No differences in measured biomarkers were observed after stratification of the exposed group into two subgroups based on the measured 131I activity below and above 6 Bq. CONCLUSION: The findings suggest that radiation protection principles based on whole-body and finger ring dosimetry, supported by activity measurements with a whole-body spectrometer, may be insufficient to monitor the absorbed dose estimation of the nuclear medicine staff who are occupationally exposed to 131I. Furthermore, their future health risks are influenced by confounders. Direct assessments comparing physical and biological dose estimations on the larger group are needed to accurately monitor occupational radiation exposure.
PURPOSE: To physically and cytogenetically screen medical personnel of Department of Endocrinology and Nuclear Medicine, Holy Cross Cancer Center, Kielce, Poland (DENM) who are occupationally exposed to 131I. MATERIALS AND METHODS: The exposure was monitored by whole-body and finger ring dosimeters. The thyroid iodine intake was measured by a whole-body spectrometer equipped with two semiconductor gamma radiation detectors. A cytokinesis-block micronucleus assay and the premature chromosome condensation technique were used to assess the aberration score. Cytogenetic analyses were carried out on a group of 29 workers and were compared to 32 controls (healthy donors), matched for gender and age. RESULTS: On average, the exposed group showed a significantly higher frequency of genetic damage and a higher proliferation index compared to the control group. Smoking status, age and duration of exposure influenced the observed effects in both groups. No differences in measured biomarkers were observed after stratification of the exposed group into two subgroups based on the measured 131I activity below and above 6 Bq. CONCLUSION: The findings suggest that radiation protection principles based on whole-body and finger ring dosimetry, supported by activity measurements with a whole-body spectrometer, may be insufficient to monitor the absorbed dose estimation of the nuclear medicine staff who are occupationally exposed to 131I. Furthermore, their future health risks are influenced by confounders. Direct assessments comparing physical and biological dose estimations on the larger group are needed to accurately monitor occupational radiation exposure.
Authors: H I Al-Mohammed; A Sulieman; Fareed H Mayhoub; Hassan Salah; Celestino Lagarde; M Alkhorayef; Ali Aldhebaib; C Kappas; D A Bradley Journal: Sci Rep Date: 2021-07-15 Impact factor: 4.379