Marwa Abdelaziz1, Ivo Krejci2, Daniel Fried3. 1. Division of Cariology and Endodontology, University Clinics of Dental Medicine (CUMD), University of Geneva, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland; Division Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA. Electronic address: Marwa.abdel@unige.ch. 2. Division of Cariology and Endodontology, University Clinics of Dental Medicine (CUMD), University of Geneva, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland. Electronic address: Ivo.krejci@unige.ch. 3. Division Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA. Electronic address: Daniel.fried@ucsf.edu.
Abstract
OBJECTIVES: The use of near infrared transillumination for caries detection is gaining recognition in daily practice. Differentiation between cavitated and non cavitated proximal lesions is recognized as a threshold for restorative treatment. This investigation focused on the use of a near infrared absorbent dye which may enhance the detection of cavitation on near infrared transillumination images. MATERIALS AND METHODS: 1: Natural teeth with artificial proximal cavitation were images with 3 different dyes to establish that near infrared absorbent dye can act like a contrast medium. 2: Natural teeth with natural cavitated lesions were used to investigate the contrast enhancing effect of indocyanine green (ICG) on near infrared transillumination images. 3: Artificial teeth with artificial cavitations were used to determine the best consistency of ICG as a contrast medium. 4: natural teeth with proximal lesions were used to confirm that ICG can differentiate between cavitated and non cavitated proximal lesions. RESULTS: 1: ICG enhanced the contrast of cavitations compared to other dyes (ANOVA; p < 0.05). 2: ICG enhanced the contrast of the cavitated area on natural lesions but not significantly (t-test; p > 0.05). 3: ICG in a gel form enhanced the detection of cavitated lesions when compared to liquid ICG (t-test; p < 0.05). 4: ICG gel was able to differentiate between cavitated and non cavitated proximal lesions (ANOVA; p < 0.05). CONCLUSION: ICG can potentially be used as a contrast medium to enhance the detection of cavitated proximal lesions in vitro on near infrared transillumination images. A clinical study is required to validate these results in vivo.
OBJECTIVES: The use of near infrared transillumination for caries detection is gaining recognition in daily practice. Differentiation between cavitated and non cavitated proximal lesions is recognized as a threshold for restorative treatment. This investigation focused on the use of a near infrared absorbent dye which may enhance the detection of cavitation on near infrared transillumination images. MATERIALS AND METHODS: 1: Natural teeth with artificial proximal cavitation were images with 3 different dyes to establish that near infrared absorbent dye can act like a contrast medium. 2: Natural teeth with natural cavitated lesions were used to investigate the contrast enhancing effect of indocyanine green (ICG) on near infrared transillumination images. 3: Artificial teeth with artificial cavitations were used to determine the best consistency of ICG as a contrast medium. 4: natural teeth with proximal lesions were used to confirm that ICG can differentiate between cavitated and non cavitated proximal lesions. RESULTS: 1: ICG enhanced the contrast of cavitations compared to other dyes (ANOVA; p < 0.05). 2: ICG enhanced the contrast of the cavitated area on natural lesions but not significantly (t-test; p > 0.05). 3: ICG in a gel form enhanced the detection of cavitated lesions when compared to liquid ICG (t-test; p < 0.05). 4: ICG gel was able to differentiate between cavitated and non cavitated proximal lesions (ANOVA; p < 0.05). CONCLUSION:ICG can potentially be used as a contrast medium to enhance the detection of cavitated proximal lesions in vitro on near infrared transillumination images. A clinical study is required to validate these results in vivo.
Authors: Matthias Jacob; Peter Conzen; Udilo Finsterer; Alexander Krafft; Bernhard F Becker; Markus Rehm Journal: J Appl Physiol (1985) Date: 2006-11-16
Authors: Patrick R Schmidlin; Matthias Zehnder; May A Zimmermann; Jörg Zimmermann; Malgorzata Roos; Jean-François Roulet Journal: Dent Mater Date: 2005-06 Impact factor: 5.304
Authors: Marwa Abdelaziz; Adele Lodi Rizzini; Tissiana Bortolotto; Giovanni Tomasso Rocca; Albert J Feilzer; Franklin Garcia-Godoy; Ivo Krejci Journal: Am J Dent Date: 2016-02 Impact factor: 1.522
Authors: Jarmo T Alander; Ilkka Kaartinen; Aki Laakso; Tommi Pätilä; Thomas Spillmann; Valery V Tuchin; Maarit Venermo; Petri Välisuo Journal: Int J Biomed Imaging Date: 2012-04-22