| Literature DB >> 31682827 |
Bo Hu1, Ying Yu1, Yu-Jie Dai2, Jia-Hao Feng3, Lin-Feng Yan1, Qian Sun1, Jin Zhang1, Yang Yang1, Yu-Chuan Hu1, Hai-Yan Nan1, Xiang-Nan Zhang4, Zhe Zheng3, Peng Qin3, Xiao-Cheng Wei5, Guang-Bin Cui6, Wen Wang7.
Abstract
Previous studies reported that long-term nociceptive stimulation could result in neurovascular coupling (NVC) dysfunction in brain, but these studies were based mainly on unimodal imaging biomarkers, thus could not comprehensively reflect NVC dysfunction. We investigated the potential NVC dysfunction in chronic migraine by exploring the relationship between neuronal activity and cerebral perfusion maps. The Pearson correlation coefficients between these 2 maps were defined as the NVC biomarkers. NVC biomarkers in migraineurs were significantly lower in left inferior parietal gyrus (IPG), left superior marginal gyrus (SMG) and left angular gyrus (AG), but significantly higher in right superior occipital gyrus (SOG), right superior parietal gyrus (SPG), and precuneus. These brain regions were located mainly in parietal or occipital lobes and were related to visual or sensory information processing. ALFF-CBF in right SPG was positively correlated with disease history and that in right precuneus was negatively correlated with migraine persisting time. fALFF-CBF in left SMG and AG were negatively related to headache frequency and positively related to health condition and disease history. In conclusion, multi-modal MRI could be used to detect NVC dysfunction in chronic migraine patients, which is a new method to assess the impact of chronic pain on the brain.Entities:
Keywords: arterial spin-labeling (ASL); blood oxygenation level dependent (BOLD); chronic migraine; functional magnetic resonance imaging (fMRI); neurovascular coupling (NVC)
Mesh：
Year: 2019 PMID： 31682827 DOI： 10.1016/j.neuroscience.2019.09.022
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590