Seyed Mohammadreza Niktabar1, Hossein Aarafi2, Seyed Alireza Dastgheib3, Mahmood Noorishadkam4, Seyed Reza Mirjalili4, Mohamad Hosein Lookzadeh4, Mohammad Javad Akbarian-Bafghi5, Majid Morovati-Sharifabad6, Hossein Neamatzadeh7,8. 1. Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 2. Department of Pediatrics, Yazd Branch, Islamic Azad University, Yazd, Iran. 3. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran. 6. Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran. 7. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 8. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
BACKGROUND: Several studies have evaluated association of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 1298A > C polymorphism with non-syndromic cleft lip with or without palate (NSCL ± P) susceptibility, however the results are inconsistent. MATERIALS AND METHODS: To address this issue, we performed a case-control study to evaluate the association of MTHFR 1298A > C polymorphism with NSCL ± P risk, followed by a meta-analysis. RESULTS: Including our study, a total of 22 case-control studies with 2,814 cases and 4,199 controls were selected. The results suggested that there was no significant association between MTHFR 1298A > C polymorphism and NSCL ± P risk overall. The subgroup analysis demonstrated that the polymorphism was significantly associated with NSCL ± P risk in Asians and Iranian populations, but not in Caucasians, mixed and Chinese populations. CONCLUSION: This meta-analysis indicates that MTHFR 1298A > C polymorphism may not contribute to NSCL ± P risk in overall. However, the MTHFR 1298A > C polymorphism was significantly associated with an increased risk of NSCL ± P in Asians and Iranian populations.
BACKGROUND: Several studies have evaluated association of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 1298A > C polymorphism with non-syndromic cleft lip with or without palate (NSCL ± P) susceptibility, however the results are inconsistent. MATERIALS AND METHODS: To address this issue, we performed a case-control study to evaluate the association of MTHFR 1298A > C polymorphism with NSCL ± P risk, followed by a meta-analysis. RESULTS: Including our study, a total of 22 case-control studies with 2,814 cases and 4,199 controls were selected. The results suggested that there was no significant association between MTHFR 1298A > C polymorphism and NSCL ± P risk overall. The subgroup analysis demonstrated that the polymorphism was significantly associated with NSCL ± P risk in Asians and Iranian populations, but not in Caucasians, mixed and Chinese populations. CONCLUSION: This meta-analysis indicates that MTHFR 1298A > C polymorphism may not contribute to NSCL ± P risk in overall. However, the MTHFR 1298A > C polymorphism was significantly associated with an increased risk of NSCL ± P in Asians and Iranian populations.