Hyun-Jae Woo1,2, Peter H Hwang2, Michael J Kaplan2, Garret Choby2,3. 1. Department of Otolaryngology-Head and Neck Surgery, CHA University School of Medicine, Gumi CHA Hospital, Gumi, Republic of Korea. 2. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California. 3. Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota.
Abstract
BACKGROUND: To identify the clinical characteristics and prognostic factors of malignancies involving the pterygopalatine fossa (PPF). METHODS: Fifty-seven patients who underwent curative surgery for malignant tumor involving PPF were reviewed. RESULTS: The rates for three-year local control (LC), five-year disease-free survival (DFS) and five-year overall survival (OS) were 55.4%, 34.5%, and 52.7%, respectively. Perineural invasion (PNI) of the maxillary nerve with facial numbness (symptomatic V2 PNI) (P = .04) and cranial involvement (P = .03) were predictors for poor OS. Symptomatic V2 PNI was also a significant predictor for poor LC (P = .05) and DFS (P = .03). Within the subgroup analysis of patients with pathologically confirmed V2 PNI, asymptomatic V2 PNI patients had significantly better LC (71.2% vs 31.8%, P = .05) and DFS (43.8% vs 17.3%, P = .05) compared to symptomatic patients. CONCLUSION: Malignant tumors involving the PPF have diverse pathologies and a poor prognosis. Symptomatic V2 PNI may be an independent poor prognostic factor.
BACKGROUND: To identify the clinical characteristics and prognostic factors of malignancies involving the pterygopalatine fossa (PPF). METHODS: Fifty-seven patients who underwent curative surgery for malignant tumor involving PPF were reviewed. RESULTS: The rates for three-year local control (LC), five-year disease-free survival (DFS) and five-year overall survival (OS) were 55.4%, 34.5%, and 52.7%, respectively. Perineural invasion (PNI) of the maxillary nerve with facial numbness (symptomatic V2 PNI) (P = .04) and cranial involvement (P = .03) were predictors for poor OS. Symptomatic V2 PNI was also a significant predictor for poor LC (P = .05) and DFS (P = .03). Within the subgroup analysis of patients with pathologically confirmed V2 PNI, asymptomatic V2 PNI patients had significantly better LC (71.2% vs 31.8%, P = .05) and DFS (43.8% vs 17.3%, P = .05) compared to symptomatic patients. CONCLUSION:Malignant tumors involving the PPF have diverse pathologies and a poor prognosis. Symptomatic V2 PNI may be an independent poor prognostic factor.
Authors: Natália C Rezende; Carlos D Pinheiro-Neto; Luciano C P C Leonel; Jamie J Van Gompel; Maria Peris-Celda; Garret Choby Journal: World J Otorhinolaryngol Head Neck Surg Date: 2022-03-22