| Literature DB >> 31680553 |
Ying-Jie Ren1,2, Yan-Gang Cao1,2, Meng-Nan Zeng1,2, Bei-Bei Zhang1,2, Yan-Ling Liu1,2, Meng-Na Wang1,2, Yan-Li Zhang1,2, Wei-Sheng Feng1,2, Xiao-Ke Zheng1,2.
Abstract
Two new norsesquiterpenoids, dioscopposin A (1) and dioscopposin B (2), as well as 21 known compounds (3-23) were isolated from the stems and leaves of Dioscorea oppositifolia L. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The absolute configurations were deduced by the comparison of experimental and calculated electronic circular dichroism spectra. Estrogenic activity of all the isolated compounds were evaluated using MCF-7 cells proliferation assay and compounds 2, 3, 7, 13, 15, 16, 18 and 21 exhibited proliferation activity.Entities:
Keywords: Dioscorea oppositifolia L.; Dioscoreaceae; estrogenic activity; norsesquiterpenoids
Year: 2019 PMID： 31680553 DOI： 10.1080/14786419.2019.1684284
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861