Literature DB >> 31679249

The Critical Role of the Antimicrobial Peptide LL-37/ CRAMP in Protection of Colon Microbiota Balance, Mucosal Homeostasis, Anti-Inflammatory Responses, and Resistance to Carcinogenesis.

Meihua Zhang1, Weiwei Liang2, Wanghua Gong3, Teizo Yoshimura4, Keqiang Chen5, Ji Ming Wang5.   

Abstract

Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infections in the colon, where the epithelium is exposed to myriad of enteric pathogens. It is increasingly recognized that LL-37/CRAMP maintains colon mucosal barrier integrity, shapes the composition of microbiota, and protects the host from tumorigenesis. In this review, we discuss the importance of LL-37/CRAMP in the homeostasis of the host, with novel findings derived from mice deficient in CRAMP that support the proposition for this natural antimicrobial peptide and an immune modulator as a drug lead for therapeutic development.

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Year:  2019        PMID： 31679249     DOI： 10.1615/CritRevImmunol.2019030225

Source DB:  PubMed          Journal:  Crit Rev Immunol        ISSN： 1040-8401            Impact factor:   2.214


  8 in total

Review 1.  Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes.

Authors:  Kasra Moeinabadi-Bidgoli; Malihe Rezaee; Hamidreza Rismanchi; Mohaddese Malek Mohammadi; Amirhesam Babajani
Journal:  Front Cell Dev Biol       Date:  2022-07-06

2.  Requirement of CRAMP for mouse macrophages to eliminate phagocytosed E. coli through an autophagy pathway.

Authors:  Keqiang Chen; Teizo Yoshimura; Wanghua Gong; Cuimeng Tian; Jiaqiang Huang; Giorgio Trinchieri; Ji Ming Wang
Journal:  J Cell Sci       Date:  2021-03-08       Impact factor: 5.285

3.  The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer.

Authors:  Cuimeng Tian; Keqiang Chen; Wanghua Gong; Teizo Yoshimura; Jiaqiang Huang; Ji Ming Wang
Journal:  Technol Cancer Res Treat       Date:  2020 Jan-Dec

4.  IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection.

Authors:  Banglao Xu; Xianan Wu; Yi Gong; Ju Cao
Journal:  Gut Microbes       Date:  2021 Jan-Dec

Review 5.  The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers.

Authors:  Anna Sobiepanek; Łukasz Kuryk; Mariangela Garofalo; Sandeep Kumar; Joanna Baran; Paulina Musolf; Frank Siebenhaar; Joachim Wilhelm Fluhr; Tomasz Kobiela; Roberto Plasenzotti; Karl Kuchler; Monika Staniszewska
Journal:  Int J Mol Sci       Date:  2022-02-17       Impact factor: 5.923

6.  Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis.

Authors:  Keqiang Chen; Teizo Yoshimura; Xiaohong Yao; Wanghua Gong; Jiaqiang Huang; Amiran K Dzutsev; John McCulloch; Colm O'hUigin; Xiu-Wu Bian; Giorgio Trinchieri; Ji Ming Wang
Journal:  J Pathol       Date:  2021-01-19       Impact factor: 7.996

7.  Colonic epithelial cathelicidin (LL-37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate.

Authors:  Ross J Porter; Graeme I Murray; Abdo Alnabulsi; Matthew P Humphries; Jacqueline A James; Manuel Salto-Tellez; Stephanie G Craig; Ji M Wang; Teizo Yoshimura; Mairi H McLean
Journal:  J Pathol Clin Res       Date:  2021-05-14

8.  Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract.

Authors:  Liam D McDonough; Animesh A Mishra; Nicholas Tosini; Pallavi Kakade; Swathi Penumutchu; Shen-Huan Liang; Corrine Maufrais; Bing Zhai; Ying Taur; Peter Belenky; Richard J Bennett; Tobias M Hohl; Andrew Y Koh; Iuliana V Ene
Journal:  mBio       Date:  2021-11-02       Impact factor: 7.867
  8 in total

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