Molly R Siegel1, Rebecca J Wolsky2,3, Edwin A Alvarez4, Biftu M Mengesha4. 1. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, Molly Siegel 550 16th Street, 7th Floor, Ob/Gyn Mailstop 0132, San Francisco, CA, 94143, USA. molly.siegel@ucsf.edu. 2. Department of Surgical Pathology, Zuckerburg San Francisco General Hospital and Trauma Center, San Francisco, USA. 3. Department of Anatomic Pathology, University of California, San Francisco, San Francisco, USA. 4. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, Molly Siegel 550 16th Street, 7th Floor, Ob/Gyn Mailstop 0132, San Francisco, CA, 94143, USA.
Abstract
PURPOSE: To present a case of struma ovarii with a typical features and synchronous primary thyroid carcinoma and review the available literature to guide diagnosis and management of these tumors. METHODS: We present a case from our hospital of a 55-year-old woman who had an adnexal mass with features concerning for papillary thyroid carcinoma and was ultimately determined to be struma ovarii with atypical features. Subsequent thyroid imaging and biopsy revealed a primary cervical thyroid carcinoma. We performed a PubMed search of published English language articles using the search terms "malignant struma ovarii," "metastatic struma ovarii," "struma ovarii with malignant transformation," "struma ovarii papillary thyroid carcinoma," "struma ovarii follicular thyroid carcinoma," and "struma ovarii with concurrent primary thyroid carcinoma." RESULTS: Literature review included 104 studies with a total of 195 patient cases. The average age at presentation was 44.9 years. 25.1% of patients had metastatic disease at presentation, and 6.2% had synchronous primary carcinomas; all of which were located in the thyroid. CONCLUSIONS: Thyroid carcinoma arising in struma ovarii or mature cystic teratoma should prompt clinical evaluation and imaging of the thyroid given the possibility of synchronous primaries, metastases, and recurrence.
PURPOSE: To present a case of struma ovarii with a typical features and synchronous primary thyroid carcinoma and review the available literature to guide diagnosis and management of these tumors. METHODS: We present a case from our hospital of a 55-year-old woman who had an adnexal mass with features concerning for papillary thyroid carcinoma and was ultimately determined to be struma ovarii with atypical features. Subsequent thyroid imaging and biopsy revealed a primary cervical thyroid carcinoma. We performed a PubMed search of published English language articles using the search terms "malignant struma ovarii," "metastatic struma ovarii," "struma ovarii with malignant transformation," "struma ovarii papillary thyroid carcinoma," "struma ovarii follicular thyroid carcinoma," and "struma ovarii with concurrent primary thyroid carcinoma." RESULTS: Literature review included 104 studies with a total of 195 patient cases. The average age at presentation was 44.9 years. 25.1% of patients had metastatic disease at presentation, and 6.2% had synchronous primary carcinomas; all of which were located in the thyroid. CONCLUSIONS:Thyroid carcinoma arising in struma ovarii or mature cystic teratoma should prompt clinical evaluation and imaging of the thyroid given the possibility of synchronous primaries, metastases, and recurrence.