| Literature DB >> 31677874 |
Leonardo Trasande1, Sandra India Aldana2, Howard Trachtman3, Kurunthachalam Kannan4, Deborah Morrison5, Dimitri A Christakis6, Kathryn Whitlock6, Mary Jo Messito5, Rachel S Gross5, Rajendiran Karthikraj4, Sheela Sathyanarayana7.
Abstract
The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects, few have examined potential effects on kidney function in children. We leveraged three cohorts across different phases of child development and measured urinary levels of glyphosate. We evaluated associations of glyphosate with three biomarkers of kidney injury: albuminuria (ACR), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury marker 1 (KIM-1). Multivariable regression analyses examined associations of glyphosate with kidney injury biomarkers controlling for covariates. We identified glyphosate in 11.1% of the total participants. The herbicide was detected more frequently in the neonate population (30%). Multivariable regression models failed to identify significant associations of log-transformed glyphosate with any of the kidney injury biomarkers, controlling for covariates age, sex, and maternal education. While we confirm detectability of glyphosate in children's urine at various ages and stages of life, there is no evidence in this study for renal injury in children exposed to low levels of glyphosate. Further studies of larger sample size are indicated to better understand putative deleterious effects of the herbicide after different levels of exposure.Entities:
Keywords: Children; Environmental exposures; Glyphosate; Nephrotoxicity; Renal biomarkers
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Year: 2019 PMID： 31677874 PMCID： PMC7307380 DOI： 10.1016/j.envpol.2019.113334
Source DB: PubMed Journal: Environ Pollut ISSN： 0269-7491 Impact factor: 8.071