Dendritic Cells Drive Osteosarcomagenesis through Newly Identified Oncogene and Tumor Suppressor.

GRM4, a GWAS-suspected tumor suppressor, is tested in a mouse model of osteosarcomagenesis as well as the putative oncogene it suppresses, IL23. Both are expressed in and exert the bulk of their influence among tumor-infiltrating myeloid-derived antigen-presenting cells, rather than osteosarcoma cells.See related article by Kansara et al., p. 1511. ©2019 American Association for Cancer Research.