Literature DB >> 31676450

Use of nucleoside phosphorylases for the preparation of 5-modified pyrimidine ribonucleosides.

Cyril S Alexeev1, Mikhail S Drenichev1, Evgeniya O Dorinova1, Roman S Esipov2, Irina V Kulikova1, Sergey N Mikhailov3.   

Abstract

Enzymatic transglycosylation, a transfer of the carbohydrate moiety from one heterocyclic base to another, is catalyzed by nucleoside phosphorylases (NPs) and is being actively developed and applied for the synthesis of biologically important nucleosides. Here, we report an efficient one-step synthesis of 5-substitited pyrimidine ribonucleosides starting from 7-methylguanosine hydroiodide in the presence of nucleoside phosphorylases (NPs).
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Enzymes; Nucleoside phosphorylases; Nucleosides; Phosphorolysis; Transglycosylation; Uridine

Mesh：

Substances：

Year:  2019        PMID： 31676450     DOI： 10.1016/j.bbapap.2019.140292

Source DB:  PubMed          Journal:  Biochim Biophys Acta Proteins Proteom        ISSN： 1570-9639            Impact factor:   3.036


  5 in total

1.  Synthesis of Fluorine-Containing Analogues of Purine Deoxynucleosides: Optimization of Enzymatic Transglycosylation Conditions.

Authors:  M S Drenichev; E O Dorinova; I V Varizhuk; V E Oslovsky; M A Varga; R S Esipov; D D Lykoshin; C S Alexeev
Journal:  Dokl Biochem Biophys       Date:  2022-05-10       Impact factor: 0.834

2.  Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases.

Authors:  Julia N Artsemyeva; Ekaterina A Remeeva; Tatiana N Buravskaya; Irina D Konstantinova; Roman S Esipov; Anatoly I Miroshnikov; Natalia M Litvinko; Igor A Mikhailopulo
Journal:  Beilstein J Org Chem       Date:  2020-10-22       Impact factor: 2.883

3.  Comparative Analysis of Enzymatic Transglycosylation Using E. coli Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2'-Deoxyribonucleosides from Ribonucleosides.

Authors:  Mikhail S Drenichev; Vladimir E Oslovsky; Anastasia A Zenchenko; Claudia V Danilova; Mikhail A Varga; Roman S Esipov; Dmitry D Lykoshin; Cyril S Alexeev
Journal:  Int J Mol Sci       Date:  2022-03-03       Impact factor: 5.923

4.  The Peculiar Case of the Hyper-thermostable Pyrimidine Nucleoside Phosphorylase from Thermus thermophilus*.

Authors:  Felix Kaspar; Peter Neubauer; Anke Kurreck
Journal:  Chembiochem       Date:  2021-01-26       Impact factor: 3.164

5.  Optimized Biocatalytic Synthesis of 2-Selenopyrimidine Nucleosides by Transglycosylation*.

Authors:  Katja F Hellendahl; Felix Kaspar; Xinrui Zhou; Zhaoyi Yang; Zhen Huang; Peter Neubauer; Anke Kurreck
Journal:  Chembiochem       Date:  2021-03-31       Impact factor: 3.164
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.