Vanessa E Cobham1, Anna Hickling2, Hayley Kimball3, Hannah J Thomas4, James G Scott5, Christel M Middeldorp6. 1. Child and Youth Mental Health Service [CYMHS], Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia; School of Psychology, The University of Queensland, Brisbane, Australia. Electronic address: vanessa@psy.uq.edu.au. 2. School of Psychology, The University of Queensland, Brisbane, Australia; Mater Research Institute, Brisbane, Queensland, Australia. 3. School of Psychology, The University of Queensland, Brisbane, Australia. 4. Queensland Centre for Mental Health Research, Brisbane, Australia, and the Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, Australia. 5. Queensland Centre for Mental Health Research, Brisbane, Australia, and the Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Metro North Mental Health Service, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia, and QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. 6. Child and Youth Mental Health Service [CYMHS], Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia, and Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: Youth with chronic medical conditions (CMCs) have been reported to be at increased risk for developing anxiety disorders. Importantly, suffering from anxiety may also have an impact on their disease-related outcomes. This study set out to systematically review the literature on anxiety and seven CMCs (asthma, congenital heart disease, diabetes, epilepsy, inflammatory bowel disease, juvenile idiopathic arthritis, and sickle cell disease) among youth. METHOD: A systematic review was performed according to the PRISMA statement. Searches were conducted across PubMed, PsycNET, Embase, and reference lists of the included studies (1990-2018). Three independent reviewers screened titles and abstracts and conducted full-text assessment. Studies were included if they reported the prevalence of anxiety or the association of anxiety on disease-related outcomes in children and/or adolescents with the focal CMCs. RESULTS: A total of 53 studies met the predetermined inclusion criteria. Across the CMCs, the prevalence of anxiety disorder was increased in youths with CMCs compared to the general population. Evidence for a relationship between anxiety and adverse disease-related outcomes was limited. For asthma, inflammatory bowel disease, and sickle cell disease, there was some evidence indicating that anxiety was associated with adverse outcomes; supported by two longitudinal studies, one in asthma and one in inflammatory bowel disease. For diabetes, results were inconsistent; with some studies indicating that anxiety was associated with worse and others with better treatment adherence. CONCLUSION: The prevalence of anxiety disorders in youth with CMCs is higher than that in the general population. Anxiety may also be associated with adverse disease-related outcomes for youths, but it is not possible to draw definitive conclusions. Longitudinal studies making use of parent/youth composite anxiety measures and a combination of parent/youth reported and objective measures of disease-related outcomes are needed. Given the burden of disease of anxiety disorders, regardless of the impact on the disease outcomes, screening for and treatment of anxiety is recommended in youths with CMCs.
OBJECTIVE: Youth with chronic medical conditions (CMCs) have been reported to be at increased risk for developing anxiety disorders. Importantly, suffering from anxiety may also have an impact on their disease-related outcomes. This study set out to systematically review the literature on anxiety and seven CMCs (asthma, congenital heart disease, diabetes, epilepsy, inflammatory bowel disease, juvenile idiopathic arthritis, and sickle cell disease) among youth. METHOD: A systematic review was performed according to the PRISMA statement. Searches were conducted across PubMed, PsycNET, Embase, and reference lists of the included studies (1990-2018). Three independent reviewers screened titles and abstracts and conducted full-text assessment. Studies were included if they reported the prevalence of anxiety or the association of anxiety on disease-related outcomes in children and/or adolescents with the focal CMCs. RESULTS: A total of 53 studies met the predetermined inclusion criteria. Across the CMCs, the prevalence of anxiety disorder was increased in youths with CMCs compared to the general population. Evidence for a relationship between anxiety and adverse disease-related outcomes was limited. For asthma, inflammatory bowel disease, and sickle cell disease, there was some evidence indicating that anxiety was associated with adverse outcomes; supported by two longitudinal studies, one in asthma and one in inflammatory bowel disease. For diabetes, results were inconsistent; with some studies indicating that anxiety was associated with worse and others with better treatment adherence. CONCLUSION: The prevalence of anxiety disorders in youth with CMCs is higher than that in the general population. Anxiety may also be associated with adverse disease-related outcomes for youths, but it is not possible to draw definitive conclusions. Longitudinal studies making use of parent/youth composite anxiety measures and a combination of parent/youth reported and objective measures of disease-related outcomes are needed. Given the burden of disease of anxiety disorders, regardless of the impact on the disease outcomes, screening for and treatment of anxiety is recommended in youths with CMCs.
Authors: Eleanor R Turi; Laura C Reigada; Jianfang Liu; Sarah I Leonard; Jean-Marie Bruzzese Journal: Ann Allergy Asthma Immunol Date: 2021-09-20 Impact factor: 6.347
Authors: Pilar Rodríguez-Rubio; Laura Lacomba-Trejo; Selene Valero-Moreno; Inmaculada Montoya-Castilla; Marián Pérez-Marín Journal: Int J Environ Res Public Health Date: 2022-03-08 Impact factor: 3.390