Literature DB >> 3167561

Metabolism of glutamate and ammonia in astrocyte: an immunocytochemical study.

T Kaneko1, R Shigemoto, N Mizuno.   

Abstract

Alpha-ketoglutarate (alpha-KG) reductive amination activity in rat brain was found to be mostly absorbed with an antibody against liver glutamate dehydrogenase. With this and anti-glutamine synthetase antibodies, alpha-KG reductive amination activity was immunocytochemically shown to coexist with glutamine synthetase activity in astrocytes. The results suggest that astrocytes de novo synthesize glutamate from alpha-KG and ammonia, and metabolize it to glutamine.

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Year:  1988        PMID： 3167561     DOI： 10.1016/0006-8993(88)90069-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

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2.  Imbalanced expression of glutamate-glutamine cycle enzymes induced by human T-cell lymphotropic virus type 1 Tax protein in cultivated astrocytes.

Authors:  H Akaoka; H Hardin-Pouzet; A Bernard; B Verrier; M F Belin; P Giraudon
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Review 4.  In situ measurements of enzyme activities in the brain.

Authors:  P Kugler
Journal:  Histochem J       Date:  1993-05

5.  Neuronal and glial marker proteins in encephalopathy associated with acute liver failure and acute hyperammonemia in the rabbit.

Authors:  M Groeneweg; R J de Knegt; A Hamberger; M Ding; S Wang; S W Schalm; K G Haglid
Journal:  Metab Brain Dis       Date:  1993-06       Impact factor: 3.584

6.  45CaCl2 autoradiography in brain from rabbits with encephalopathy from acute liver failure or acute hyperammonemia.

Authors:  R J de Knegt; J B Gramsbergen; S W Schalm
Journal:  Metab Brain Dis       Date:  1994-06       Impact factor: 3.584

7.  Evidence for glutamate as a neuroglial transmitter within sensory ganglia.

Authors:  Ling-Hsuan Kung; Kerui Gong; Mary Adedoyin; Johnson Ng; Aditi Bhargava; Peter T Ohara; Luc Jasmin
Journal:  PLoS One       Date:  2013-07-02       Impact factor: 3.240
  7 in total

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