| Literature DB >> 31675495 |
Vassilis Gorgoulis1, Peter D Adams2, Andrea Alimonti3, Dorothy C Bennett4, Oliver Bischof5, Cleo Bishop6, Judith Campisi7, Manuel Collado8, Konstantinos Evangelou9, Gerardo Ferbeyre10, Jesús Gil11, Eiji Hara12, Valery Krizhanovsky13, Diana Jurk14, Andrea B Maier15, Masashi Narita16, Laura Niedernhofer17, João F Passos14, Paul D Robbins17, Clemens A Schmitt18, John Sedivy19, Konstantinos Vougas20, Thomas von Zglinicki21, Daohong Zhou22, Manuel Serrano23, Marco Demaria24.
Abstract
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.Mesh：
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Year: 2019 PMID： 31675495 DOI： 10.1016/j.cell.2019.10.005
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582