Literature DB >> 31674614

Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid.

Daniel Chavarria1, Carlos Fernandes2, Tiago Silva1, Jorge Garrido3, Fernando Remião4, Paulo J Oliveira5, Fernanda Borges2.   

Abstract

We report the synthesis of 4-thioferulic acid (TFA), a new ferulic acid (FA) derivative, and highlight the differences between the two compounds concerning rate and mechanism of radical scavenging activity, redox potential, acidity of the phenol/thiophenol moieties, cytotoxicity in differentiated SH-SY5Y cells, and neuroprotection against hydrogen peroxide (H2O2) and tert-butyl hydroperoxide (t-BHP) in the same cellular model.

Entities:  

Year:  2019        PMID： 31674614     DOI： 10.1039/c9ob01875a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  Synthesis and Antioxidant Activity of New Catechol Thioethers with the Methylene Linker.

Authors:  Ivan V Smolyaninov; Daria A Burmistrova; Maxim V Arsenyev; Maria A Polovinkina; Nadezhda P Pomortseva; Georgy K Fukin; Andrey I Poddel'sky; Nadezhda T Berberova
Journal:  Molecules       Date:  2022-05-16       Impact factor: 4.927

2.  Versatile Polymer Nanocapsules via Redox Competition.

Authors:  Jiajing Zhou; Ming Xu; Zhicheng Jin; Raina M Borum; Nicole Avakyan; Yong Cheng; Wonjun Yim; Tengyu He; Jingcheng Zhou; Zhuohong Wu; Yash Mantri; Jesse V Jokerst
Journal:  Angew Chem Int Ed Engl       Date:  2021-11-05       Impact factor: 15.336

3.  Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues.

Authors:  Daniel Chavarria; Carlos Fernandes; Brandon Aguiar; Tiago Silva; Jorge Garrido; Fernando Remião; Paulo J Oliveira; Eugenio Uriarte; Fernanda Borges
Journal:  Molecules       Date:  2019-12-02       Impact factor: 4.411

Review 4.  Role of Sulphur and Heavier Chalcogens on the Antioxidant Power and Bioactivity of Natural Phenolic Compounds.

Authors:  Maria Laura Alfieri; Lucia Panzella; Riccardo Amorati; Alice Cariola; Luca Valgimigli; Alessandra Napolitano
Journal:  Biomolecules       Date:  2022-01-06
  4 in total

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