Literature DB >> 316742

Attenuated recombinant strains of Vibrio cholerae for oral immunization.

B S Srivastava, V B Sinha, R Srivastava.   

Abstract

Two attenuated strains of Vibrio cholerae, CD1 and CD3, have been isolated that have remained stable since 1976. These strains are motile, adhere to and multiply in rabbit intestine, and colonize the gut of infant mice for 6-7 days. Both strains are antigenic and provide protection to challenge in the mouse protection test and in the rabbit ileal loop model. Because of their ability to adhere to and colonize the gut, and since they are antigenic, strains CD1 and CD3 have the potentiality of oral vaccines.

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Year:  1979        PMID： 316742      PMCID： PMC2395838     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  12 in total

1.  Experimental cholera in infant rabbits: a method for chemotherapeutic investigation.

Authors:  N K DUTTA; M K HABBU
Journal:  Br J Pharmacol Chemother       Date:  1955-06

2.  Attenuation of virulence by P and V plasmids in Vibrio cholerae: strains suitable for oral immunization.

Authors:  V B Sinha; B S Srivastava
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

3.  Motility as a virulence factor for Vibrio cholerae.

Authors:  M N Guentzel; L J Berry
Journal:  Infect Immun       Date:  1975-05       Impact factor: 3.441

4.  Mannose-sensitive haemagglutinins in adherence of Vibrio cholerae eltor to intestine.

Authors:  J W Bhattacharjee; B S Srivastava
Journal:  J Gen Microbiol       Date:  1978-08

5.  Development of improved cholera vaccine based on subunit toxoid.

Authors:  J Holmgren; A M Svennerholm; I Lönnroth; M Fall-Persson; B Markman; H Lundbeck
Journal:  Nature       Date:  1977-10-13       Impact factor: 49.962

6.  A streptomycin-sensitive revertant of a streptomycin-dependent strain of Vibrio cholerae.

Authors:  V B Sinha; J W Bhattacharjee
Journal:  Bull World Health Organ       Date:  1976       Impact factor: 9.408

7.  Adherence of wild-type and mutant strains of Vibrio cholerae to normal and immune intestinal tissue.

Authors:  J W Bhattacharjee; B S Srivastava
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

8.  Vibrio cholerae adherence and colonization in experimental cholera: electron microscopic studies.

Authors:  E T Nelson; J D Clements; R A Finkelstein
Journal:  Infect Immun       Date:  1976-08       Impact factor: 3.441

9.  Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial.

Authors:  D M Mel; A L Terzin; L Vuksić
Journal:  Bull World Health Organ       Date:  1965       Impact factor: 9.408

10.  Controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in Calcutta.

Authors:  A Das Gupta; R Sinha; D L Shrivastava; S P De; B L Taneja; M S Rao; A H Abou-Gareeb
Journal:  Bull World Health Organ       Date:  1967       Impact factor: 9.408
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