Literature DB >> 31673464

Metformin Intoxication with Severe Renal Damage: An Adolescent Case Report.

Ahmet Yontem1, Nagehan Aslan1, Ozden Ozgur Horoz1, Aysun Karabay Beyazit2, Engin Melek2, Dincer Yildizdas1.   

Abstract

Metformin is an oral antidiabetic medication which belongs to the class biguanide. Its most hazardous and life-threatening side effect is lactic acidosis which has been increasingly reported in recent years. Early diagnosis and aggressive treatment approaches have significantly reduced morbidity and mortality rates in metformin intoxication. In this case report, we emphasize the importance of early continuous renal replacement therapy in metformin-associated lactic acidosis in a 16-year-old patient who developed severe renal damage during the follow-up period of renal replacement therapy due to lactic acidosis after taking metformin in a suicide attempt. © Thieme Medical Publishers.

Entities:  

Keywords:  lactic acidosis; metformin; overdose; renal replacement therapy

Year:  2019        PMID: 31673464      PMCID: PMC6821537          DOI: 10.1055/s-0039-1695046

Source DB:  PubMed          Journal:  J Pediatr Intensive Care        ISSN: 2146-4626


  12 in total

1.  Severe metformin intoxication with lactic acidosis in an adolescent.

Authors:  Martin Lacher; Maren Hermanns-Clausen; Karsten Haeffner; Matthias Brandis; Martin Pohl
Journal:  Eur J Pediatr       Date:  2005-02-24       Impact factor: 3.183

2.  Consequences of metformin intoxication.

Authors:  J D Lalau; C Mourlhon; A Bergeret; C Lacroix
Journal:  Diabetes Care       Date:  1998-11       Impact factor: 19.112

3.  Bicarbonate haemodialysis as a treatment of metformin overdose.

Authors:  D Heaney; A Majid; B Junor
Journal:  Nephrol Dial Transplant       Date:  1997-05       Impact factor: 5.992

Review 4.  Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'.

Authors:  J D Lalau; J M Race
Journal:  Diabetes Obes Metab       Date:  2001-06       Impact factor: 6.577

Review 5.  Lactic acidosis induced by metformin: incidence, management and prevention.

Authors:  Jean-Daniel Lalau
Journal:  Drug Saf       Date:  2010-09-01       Impact factor: 5.606

6.  Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.

Authors:  S Dichtwald; A A Weinbroum; P Sorkine; M P Ekstein; E Dahan
Journal:  Diabet Med       Date:  2012-02       Impact factor: 4.359

Review 7.  Metformin revisited: a critical review of the benefit-risk balance in at-risk patients with type 2 diabetes.

Authors:  A J Scheen; N Paquot
Journal:  Diabetes Metab       Date:  2013-03-23       Impact factor: 6.041

8.  Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.

Authors:  Anders Frid; Gunnar N Sterner; Magnus Löndahl; Clara Wiklander; Anne Cato; Ellen Vinge; Anders Andersson
Journal:  Diabetes Care       Date:  2010-03-09       Impact factor: 19.112

9.  Lacticemia After Acute Overdose of Metformin in an Adolescent Managed Without Intravenous Sodium Bicarbonate or Extracorporeal Therapy.

Authors:  Vikhyat S Bebarta; Joshua Pead; Shawn M Varney
Journal:  Pediatr Emerg Care       Date:  2015-08       Impact factor: 1.454

10.  Management of metformin-associated lactic acidosis by continuous renal replacement therapy.

Authors:  Geoffray Keller; Martin Cour; Romain Hernu; Julien Illinger; Dominique Robert; Laurent Argaud
Journal:  PLoS One       Date:  2011-08-11       Impact factor: 3.240

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