B Jamilson Araújo Pereira1, A Nogueira de Almeida2, W Silva Paiva3, P Henrique Pires de Aguiar3, M Jacobsen Teixeira3, S Kazue Nagahashi Marie3. 1. Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo, Rua Martiniano de Carvalho, 669, Edifício Paulista Paradise Life, Apto 1105, Brasil. Electronic address: benedito.jamilson@hotmail.com. 2. Divisão de Neurocirurgia Funcional IPQ. Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brasil. 3. Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo, Rua Martiniano de Carvalho, 669, Edifício Paulista Paradise Life, Apto 1105, Brasil.
Abstract
PURPOSE: Review the published data on spinal meningioma (SM) to create a more comprehensive picture of its natural history. METHODS: A review of the published SM literature was carried out through a Medline search up to December 2018. The search using the keyword "spinal meningiomas" returned 248 papers and the parameters analyzed in our present study were examined in those publications. Papers without a detailed description of clinical findings, neuroimaging confirmation of the spinal tumor, minimum follow-up of 5 years, or a clear description of the clinical findings were excluded. RESULTS: In the 24 manuscripts reviewed, 1811 (1450 females/361 males) patients with SM were analyzed. The thoracic spine (1181-64.6%) and cervical spine (394-22.7%) were the more prevalent levels. The psammomatous (27.8%) and meningothelial variants (25.2%) were the most prevalent histopathological subtypes. Gross total resection (Simpson I and II) was achieved in 94.5% of cases and subtotal resection (Simpson III or more) in 5.5%. The tumor recurrence rate was 4.4%, and the mortality rate related to surgery or disease progression was 3%. CONCLUSION: WHO grade I predominance was observed among spinal meningiomas, analogous to intracranial meningiomas. SMs predominated in the thoracic spine. Surgery with gross total resection was achieved in the vast majority of cases, resulting in low recurrence and mortality rates.
PURPOSE: Review the published data on spinal meningioma (SM) to create a more comprehensive picture of its natural history. METHODS: A review of the published SM literature was carried out through a Medline search up to December 2018. The search using the keyword "spinal meningiomas" returned 248 papers and the parameters analyzed in our present study were examined in those publications. Papers without a detailed description of clinical findings, neuroimaging confirmation of the spinal tumor, minimum follow-up of 5 years, or a clear description of the clinical findings were excluded. RESULTS: In the 24 manuscripts reviewed, 1811 (1450 females/361 males) patients with SM were analyzed. The thoracic spine (1181-64.6%) and cervical spine (394-22.7%) were the more prevalent levels. The psammomatous (27.8%) and meningothelial variants (25.2%) were the most prevalent histopathological subtypes. Gross total resection (Simpson I and II) was achieved in 94.5% of cases and subtotal resection (Simpson III or more) in 5.5%. The tumor recurrence rate was 4.4%, and the mortality rate related to surgery or disease progression was 3%. CONCLUSION: WHO grade I predominance was observed among spinal meningiomas, analogous to intracranial meningiomas. SMs predominated in the thoracic spine. Surgery with gross total resection was achieved in the vast majority of cases, resulting in low recurrence and mortality rates.
Authors: Christopher Marvin Jesse; Pablo Alvarez Abut; Jonathan Wermelinger; Andreas Raabe; Ralph T Schär; Kathleen Seidel Journal: Cancers (Basel) Date: 2022-08-18 Impact factor: 6.575
Authors: Jenny Pettersson-Segerlind; Ann-Christin von Vogelsang; Alexander Fletcher-Sandersjöö; Charles Tatter; Tiit Mathiesen; Erik Edström; Adrian Elmi-Terander Journal: Cancers (Basel) Date: 2021-12-19 Impact factor: 6.639