F Z Elfatoiki1, A Boumezzourh2, H Maksouri3, N Elkhalfaoui3, M Dessay4, M Riyad5, S Chiheb6. 1. Service de dermatologie vénérologie, faculté de médecine et pharmacie, université Hassan II de Casablanca, CHU Ibn Rochd, Casablanca, Maroc. Electronic address: Fatiza59@hotmail.fr. 2. Laboratoire de biologie, CHP My Ali Cherif, Errachidia, Maroc. 3. Équipe de recherche sur les leishmanioses cutanées, faculté de médecine et pharmacie, université Hassan II de Casablanca, Casablanca, Maroc; Centre des études doctorales des sciences de la santé (FD. Immunopathologie), faculté de médecine et pharmacie, université Hassan II de Casablanca, Casablanca, Maroc. 4. Équipe de recherche sur les leishmanioses cutanées, faculté de médecine et pharmacie, université Hassan II de Casablanca, Casablanca, Maroc; Centre des études doctorales des sciences fondamentales et appliquées (FD. des sciences biologiques), faculté des sciences d'Ain Chock, université Hassan II de Casablanca, Casablanca, Maroc. 5. Équipe de recherche sur les leishmanioses cutanées, faculté de médecine et pharmacie, université Hassan II de Casablanca, Casablanca, Maroc; Laboratoire de parasitologie, faculté de médecine et pharmacie, université Hassan II de Casablanca, Casablanca, Maroc. 6. Service de dermatologie vénérologie, faculté de médecine et pharmacie, université Hassan II de Casablanca, CHU Ibn Rochd, Casablanca, Maroc; Équipe de recherche sur les leishmanioses cutanées, faculté de médecine et pharmacie, université Hassan II de Casablanca, Casablanca, Maroc.
Abstract
BACKGROUND: Cutaneous leishmaniasis is endemic in Morocco. Mucosal involvement is rare. We report a case in Morocco of cutaneous leishmaniasis of the vermilion border of the upper lip extending to the oral mucosa due to Leishmania tropica. PATIENTS AND METHODS: A 15-year-old girl was seen with 2 ulcerated lesions, present for 4 months, situated on the left cheek and vermilion border and extending to the oral mucosa. The diagnosis of leishmaniasis was confirmed by direct examination revealing high numbers of Leishmania amastigotes. Culture of the offending organism in NNN medium and isoenzymatic characterization resulted in identification of L. tropica. Treatment with meglumine antimoniate (Glucantime) was ineffective. The outcome was good after treatment with fluconazole. CONCLUSION: In Morocco, cutaneous leishmaniasis with mucosal involvement is rare, and usually develops as a complication of cutaneous leishmaniasis via direct extension.
BACKGROUND:Cutaneous leishmaniasis is endemic in Morocco. Mucosal involvement is rare. We report a case in Morocco of cutaneous leishmaniasis of the vermilion border of the upper lip extending to the oral mucosa due to Leishmania tropica. PATIENTS AND METHODS: A 15-year-old girl was seen with 2 ulcerated lesions, present for 4 months, situated on the left cheek and vermilion border and extending to the oral mucosa. The diagnosis of leishmaniasis was confirmed by direct examination revealing high numbers of Leishmania amastigotes. Culture of the offending organism in NNN medium and isoenzymatic characterization resulted in identification of L. tropica. Treatment with meglumine antimoniate (Glucantime) was ineffective. The outcome was good after treatment with fluconazole. CONCLUSION: In Morocco, cutaneous leishmaniasis with mucosal involvement is rare, and usually develops as a complication of cutaneous leishmaniasis via direct extension.