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Literature DB >> 3167140

Limbic pathology in schizophrenia: the entorhinal region--a morphometric study.

Abstract

The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with the hypothesis that structural changes in the medial temporal lobe of schizophrenics may be developmental in origin.

Entities: Disease

Mesh：

Year: 1988 PMID： 3167140 DOI： 10.1016/0006-3223(88)90162-x

Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382

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Cited

44 in total

1. Hippocampal pyramidal cell disarray correlates negatively to cell number: implications for the pathogenesis of schizophrenia.

Authors: S A Jönsson; A Luts; N Guldberg-Kjaer; A Brun
Journal: Eur Arch Psychiatry Clin Neurosci Date: 1997 Impact factor: 5.270

2. Understanding schizophrenia.

Authors: L S Pilowsky
Journal: BMJ Date: 1992-08-08

Review 3. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications.

Authors: Paul J Harrison
Journal: Psychopharmacology (Berl) Date: 2004-03-06 Impact factor: 4.530

Review 4. The brain in schizophrenia.

Authors: M A Ron; I Harvey
Journal: J Neurol Neurosurg Psychiatry Date: 1990-09 Impact factor: 10.154

Limbic pathology in schizophrenia: the entorhinal region--a morphometric study.

1. Hippocampal pyramidal cell disarray correlates negatively to cell number: implications for the pathogenesis of schizophrenia.

2. Understanding schizophrenia.

Review 3. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications.

Review 4. The brain in schizophrenia.

5. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

6. Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains.

7. Serotonergic modulation of Neural activities in the entorhinal cortex.

8. Antibodies to brain tissue in sera of schizophrenic patients--preliminary findings.

9. A quantitative magnetic resonance imaging study of patients with schizophrenia.

10. A case study of temporal lobe development in familial schizophrenia.