Literature DB >> 31671361

Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder.

Mai Moaaz1, Sara Youssry2, Amr Elfatatry3, Mohammed Abd El Rahman4.   

Abstract

We aimed in this study to investigate a possible involvement of Th17/Treg cells imbalance in autism spectrum disorders (ASD). Using flowcytometry to determine circulating Th17 and Treg cells percentages, RT- PCR and ELISA for cytokine expression, we demonstrated that Th17/Treg balance in ASD children was significantly skewed toward a Th17 response compared to their control. Th17 cells and the ratio of Th17/Treg cells had a significantly positive correlation with disease severity whereas Treg cells had a negative correlation. The imbalance of Th17, Treg cells and their related cytokines may play a vital role in the progression of the disease.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Autism spectrum disorders (ASD); Cytokines; Th17 lymphocytes; Treg lymphocytes

Mesh：

Substances：

Year:  2019        PMID： 31671361     DOI： 10.1016/j.jneuroim.2019.577071

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


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