Aiping Zhang1, Li Ning2, Jianping Han1, Yi Ma1, Yingbo Ma1, Wenjun Cao1,2,3, Xinghuai Sun2,3,4,5, Shengjie Li1,2,3,4,5. 1. Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China. 2. Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China. 3. State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China. 4. Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. 5. NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.
Abstract
Purpose: To evaluate blood count-derived inflammation indexes as a detection or predictive marker for neovascular glaucoma (NVG) secondary to retinal vein occlusion (RVO) and diabetic retinopathy (DR). Methods: This was a retrospective, case-control study design. The level of white blood cell (WBC), neutrophil (N), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) were evaluated in NVG patients secondary to RVO or DR. Results: A significant difference was found in those biomarkers between control group and NVG secondary to RVO or DR. Logistic regression analysis revealed these indexes were associated with the risk of NVG in DR and RVO patients. Multiple linear regression analysis showed a significant correlation between NLR and visual fields mean deviation in the NVG-RVO group.Conclusions: This study indicated that WBC, N, NLR, and LMR were related to NVG, and NLR may be useful as an potential inflammation biomarker indicating the risk and severity for NVG secondary to RVO.
Purpose: To evaluate blood count-derived inflammation indexes as a detection or predictive marker for neovascular glaucoma (NVG) secondary to retinal vein occlusion (RVO) and diabetic retinopathy (DR). Methods: This was a retrospective, case-control study design. The level of white blood cell (WBC), neutrophil (N), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) were evaluated in NVGpatients secondary to RVO or DR. Results: A significant difference was found in those biomarkers between control group and NVG secondary to RVO or DR. Logistic regression analysis revealed these indexes were associated with the risk of NVG in DR and RVOpatients. Multiple linear regression analysis showed a significant correlation between NLR and visual fields mean deviation in the NVG-RVO group.Conclusions: This study indicated that WBC, N, NLR, and LMR were related to NVG, and NLR may be useful as an potential inflammation biomarker indicating the risk and severity for NVG secondary to RVO.