| Literature DB >> 31668960 |
Alexandre A Steiner1, Andrej A Romanovsky2.
Abstract
Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers.Entities:
Keywords: fever; hypothermia; immunity; inflammation; resistance; tolerance
Mesh:
Year: 2019 PMID: 31668960 DOI: 10.1016/j.tem.2019.08.012
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN: 1043-2760 Impact factor: 12.015