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Literature DB >> 31668857

A Genetic Instruction Code Based on DNA Conformation.

Abstract

Flipons are sequences capable of forming either right- or left-handed DNA under physiological conditions, forming a class of dissipative structures that trade metabolic energy for information by cycling DNA between different chromatin states. Flipons enhance the diversity of transcriptomes, increasing entropy while enabling the evolution of features both new and unexpected.

Keywords: Z-DNA Z-RNA; dissipative structure; entropy; evolution; flipon; genetic code

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Year: 2019 PMID： 31668857 DOI： 10.1016/j.tig.2019.09.007

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

7 in total

1. Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?

Authors: Alan Herbert; Maria Poptsova
Journal: Front Immunol Date: 2022-06-17 Impact factor: 8.786

Review 2. To "Z" or not to "Z": Z-RNA, self-recognition, and the MDA5 helicase.

Authors: Alan Herbert
Journal: PLoS Genet Date: 2021-05-13 Impact factor: 5.917

3. Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction.

Authors: Paul R Marshall; Qiongyi Zhao; Xiang Li; Wei Wei; Ambika Periyakaruppiah; Esmi L Zajaczkowski; Laura J Leighton; Sachithrani U Madugalle; Dean Basic; Ziqi Wang; Jiayu Yin; Wei-Siang Liau; Ankita Gupte; Carl R Walkley; Timothy W Bredy
Journal: Nat Neurosci Date: 2020-05-04 Impact factor: 24.884

A Genetic Instruction Code Based on DNA Conformation.

1. Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?

Review 2. To "Z" or not to "Z": Z-RNA, self-recognition, and the MDA5 helicase.

3. Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction.

Review 4. The Simple Biology of Flipons and Condensates Enhances the Evolution of Complexity.

5. Lone Pair…π Contacts and Structure Signatures of r(UNCG) Tetraloops, Z-Turns, and Z-Steps: A WebFR3D Survey.

6. Deep learning approach for predicting functional Z-DNA regions using omics data.

Review 7. Mono a Mano: ZBP1's Love-Hate Relationship with the Kissing Virus.