Afnan M Aladdad1, Karl E Kador1. 1. Department of Ophthalmology and Department of Biomedical Sciences, University of Missouri - Kansas City, School of Medicine, Kansas City, MO 64108.
Abstract
PURPOSE: Retinal degenerative diseases lead to the death of retinal neurons causing visual impairment and blindness. In lower order vertebrates, the retina and its surrounding tissue contain stem cell niches capable of regenerating damaged tissue. Here we examine these niches and review their capacity to be used as retinal stem/progenitor cells (RSC/RPCs) for retinal repair. RECENT FINDINGS: Exogenous factors can control the in vitro activation of RSCs/PCs found in several niches within the adult eye including cells in the ciliary margin, the retinal pigment epithelium, iris pigment epithelium as well as the inducement of Müller and amacrine cells within the neural retina itself. Recently, factors have been identified for the activation of adult mammalian Müller cells to a RPC state in vivo. SUMMARY: Whereas cell transplantation still holds potential for retinal repair, activation of the dormant native regeneration process may lead to a more successful process including greater integration efficiency and proper synaptic targeting.
PURPOSE: Retinal degenerative diseases lead to the death of retinal neurons causing visual impairment and blindness. In lower order vertebrates, the retina and its surrounding tissue contain stem cell niches capable of regenerating damaged tissue. Here we examine these niches and review their capacity to be used as retinal stem/progenitor cells (RSC/RPCs) for retinal repair. RECENT FINDINGS: Exogenous factors can control the in vitro activation of RSCs/PCs found in several niches within the adult eye including cells in the ciliary margin, the retinal pigment epithelium, iris pigment epithelium as well as the inducement of Müller and amacrine cells within the neural retina itself. Recently, factors have been identified for the activation of adult mammalian Müller cells to a RPC state in vivo. SUMMARY: Whereas cell transplantation still holds potential for retinal repair, activation of the dormant native regeneration process may lead to a more successful process including greater integration efficiency and proper synaptic targeting.
Authors: Erik O Johnsen; Rebecca C Frøen; Ole Kristoffer Olstad; Bjørn Nicolaissen; Goran Petrovski; Morten C Moe; Agate Noer Journal: Curr Eye Res Date: 2017-11-21 Impact factor: 2.424
Authors: Rebecca C Frøen; Erik O Johnsen; Goran Petrovski; Erika Berényi; Andrea Facskó; András Berta; Bjørn Nicolaissen; Morten C Moe Journal: Acta Ophthalmol Date: 2011-07-29 Impact factor: 3.761
Authors: Kenneth N Grisé; Nelson X Bautista; Krystal Jacques; Brenda L K Coles; Derek van der Kooy Journal: Stem Cell Res Ther Date: 2021-01-25 Impact factor: 6.832