| Literature DB >> 31666328 |
Burcu Tepekule1, Pia Abel Zur Wiesch2,3, Roger D Kouyos4,5, Sebastian Bonhoeffer6.
Abstract
To understand how antibiotic use affects the risk of a resistant infection, we present a computational model of the population dynamics of gut microbiota including antibiotic resistance-conferring plasmids. We then describe how this model is parameterized based on published microbiota data. Finally, we investigate how treatment history affects the prevalence of resistance among opportunistic enterobacterial pathogens. We simulate treatment histories and identify which properties of prior antibiotic exposure are most influential in determining the prevalence of resistance. We find that resistance prevalence can be predicted by 3 properties, namely the total days of drug exposure, the duration of the drug-free period after last treatment, and the center of mass of the treatment pattern. Overall this work provides a framework for capturing the role of the microbiome in the selection of antibiotic resistance and highlights the role of treatment history for the prevalence of resistance.Entities:
Keywords: gut microbiota; plasmid-mediated resistance; prior treatment; risk factor
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Year: 2019 PMID： 31666328 PMCID： PMC6859334 DOI： 10.1073/pnas.1912188116
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205