| Literature DB >> 31666148 |
Lannie Ligthart1,2, Catharina E M van Beijsterveldt1,2, Sofieke T Kevenaar1,2, Eveline de Zeeuw1,2, Elsje van Bergen1,2, Susanne Bruins1,2, René Pool1,2, Quinta Helmer1,2, Jenny van Dongen1,2, Jouke-Jan Hottenga1,2, Dennis Van't Ent1,2, Conor V Dolan1,2, Gareth E Davies3, Erik A Ehli3, Meike Bartels1,2, Gonneke Willemsen1,2, Eco J C de Geus1,2, Dorret I Boomsma1,2.
Abstract
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.Keywords: Twins; biobank; endophenotyping; longitudinal phenotyping; multigeneration pedigree; zygosity
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Year: 2019 PMID： 31666148 DOI： 10.1017/thg.2019.93
Source DB: PubMed Journal: Twin Res Hum Genet ISSN： 1832-4274 Impact factor: 1.587