Literature DB >> 31666105

Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.

Kai Teng1, Shi Wei1, Chi Zhang1, Jiewei Chen2, Jinbin Chen1,3, Kanghua Xiao1,4, Jun Liu2, Miaomiao Dai1, Xinyuan Guan1, Jingping Yun2, Dan Xie5,6.   

Abstract

In the original publication of this article [1], the indicated stages (I-II III-IV) were missing in the clinical stage part at both Table 1 and Table 2.

Entities:  

Year:  2019        PMID: 31666105      PMCID: PMC6822465          DOI: 10.1186/s13046-019-1460-0

Source DB:  PubMed          Journal:  J Exp Clin Cancer Res        ISSN: 0392-9078


Correction to: J Exp Clin Cancer Res (2019) 38: 329 https://doi.org/10.1186/s13046-019-1331-8 In the original publication of this article [1], the indicated stages (I-II III-IV) were missing in the clinical stage part at both Table 1 and Table 2. The revised tables are shown below.
Table 1

Correlation expression of KIFC1 and clinicopathological parameters in 168 HCC cases in SYSUCC cohort

VariableAll cases (N = 168)KIFC1 expression (%)P values
Low expression (N = 97)High expression (N = 71)
Age (years)0.763
 ≤ 519051 (56.7)39 (43.3)
 > 517846 (59.0)32 (41.0)
Sex0.849
 Male14383 (58.0)60 (42.0)
 Female2514 (56.0)11 (44.0)
AFP (ng/ml)0.652
 ≤ 207243 (59.7)29 (40.3)
 > 209654 (56.3)42 (43.7)
HBsAg0.394
 negative115 (45.5)6 (54.5)
 positive15792 (58.6)65 (41.4)
Cirrhosis0.713
 No9956 (56.6)43 (43.4)
 Yes6941 (59.4)28 (40.6)
Necrosis0.506
 No7646 (60.5)30 (39.5)
 Yes9251 (55.4)41 (44.6)
Clinical stage0.009
 I-II11172 (64.9)39 (35.1)
 III-IV5725 (43.9)32 (56.1)
Histologic grade (WHO)0.113
 G1-G28353 (63.9)30 (36.1)
 G3-G4*8544 (51.8)41 (48.2)
Tumor size (cm)0.031
 ≤ 57349 (67.1)24 (32.9)
 > 59548 (50.5)47 (49.5)
Tumor multiplicity0.688
 Unifocal12875 (58.6)53 (41.4)
 Multifocal4022 (55.0)18 (45.0)
Intravascular emboli0.688
 No10059 (59.0)41 (41.0)
 Yes6838 (55.9)30 (44.1)
Recurrence0.037
 No12578 (62.4)47 (37.6)
 Yes4319 (44.2)24 (55.8)

*:including 3 cases sarcomatoid liver cancer

Table 2

Univariate and multivariate analysis of different prognostic parameters in 168 HCC patients

VariableUnivariate analysisMultivariate analysis
All casesMean survival (months)p ValueHR (95% CI)p Value
Age (years)0.339
 ≤ 519049.799
 > 517869.089
Sex0.061
 Male14369.106
 Female2543.696
AFP (ng/ml)0.055
 ≤ 207272.295
 > 209653.431
HBsAg0.329
 negative1159.111
 positive15766.402
Cirrhosis0.829
 No9957.617
 Yes6966.272
Necrosis0.179
 No7660.350
 Yes9263.514
Clinical stage0.0000.000
 I-II11165.8131
 III-IV5743.7785.173 (2.456–10.894)
Histologic grade (WHO)0.0000.035
 G1-G28265.2541
 G3-G4*8655.8822.334 (1.063–5.126)
Tumor size (cm)0.0170.915
 ≤ 57374.428
 > 59549.049
Tumor multiplicity0.0000.478
 Unifocal12861.089
 Multifocal4050.483
Intravascular emboli0.0130.483
 No10061.257
 Yes6859.172
Recurrence0.0070.061
 No12570.974
 Yes4344.667
KIFC10.0020.012
 Low74.1531
 High45.5682.371 (1.207–4.660)

*:including 3 cases sarcomatoid liver cancer

Correlation expression of KIFC1 and clinicopathological parameters in 168 HCC cases in SYSUCC cohort *:including 3 cases sarcomatoid liver cancer Univariate and multivariate analysis of different prognostic parameters in 168 HCC patients *:including 3 cases sarcomatoid liver cancer The authors sincerely apologize for the inconvenience caused to the readers.
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1.  KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.

Authors:  Kai Teng; Shi Wei; Chi Zhang; Jiewei Chen; Jinbin Chen; Kanghua Xiao; Jun Liu; Miaomiao Dai; Xinyuan Guan; Jingping Yun; Dan Xie
Journal:  J Exp Clin Cancer Res       Date:  2019-07-24
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