Thiago Huaytalla Silva1, Arthur Orlando Corrêa Schilithz1, Wilza Arantes Ferreira Peres2, Leonardo Borges Murad1,3. 1. Surveillance and Situation Analysis Division, Brazilian National Cancer Institute José Alencar Gomes da Silva (INCA), Rio De Janeiro, RJ, Brazil. 2. Department of Nutrition and Dietetics Federal University of Rio De Janeiro, Rio De Janeiro, RJ, Brazil. 3. Nutrition and Dietetics Section Brazilian National Cancer Institute José Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil.
Abstract
Background: Neutrophil-lymphocyte ratio (NLR) and nutritional status may provide a prognostic value in colorectal cancer (CRC). Thus, aim of this study was to evaluate the prognostic value of nutritional status and NLR in CRC patients. Methods: A retrospective analysis was conducted in CRC patients. The independent variables were body mass index (BMI), weight loss (WL) and NLR. Logistic regression was used to estimate the odds chance of low NLR. Kaplan-Meier curves and Cox regression were used to evaluate the overall survival at 5 years old. Results: In the 148 patients evaluated, the most prevalent nutritional status was overweight/obesity (43.2%) and 27.0% had severe WL. Sixty-seven subjects (45.3%) had NLR ≥ 3 that was associated with the lower OS (P < 0.001). There was a higher OS for overweight/obese patients (P = 0.002) and a lower among subjects with severe WL (P = 0.009). The NLR ≥3 (HR: 3.639; 95% CI, 1.708-7.771) was an independent poor prognostic factor for OS. Patients without WL (HR: 0.367, 95% CI, 0.141-0.954) and classified as overweight/obesity (HR: 0.260; 95% CI, 0.106-0.639) presented better prognostic. Conclusion: NLR, WL, BMI assessments are promising prognostic indicators in the CRC.
Background: Neutrophil-lymphocyte ratio (NLR) and nutritional status may provide a prognostic value in colorectal cancer (CRC). Thus, aim of this study was to evaluate the prognostic value of nutritional status and NLR in CRCpatients. Methods: A retrospective analysis was conducted in CRCpatients. The independent variables were body mass index (BMI), weight loss (WL) and NLR. Logistic regression was used to estimate the odds chance of low NLR. Kaplan-Meier curves and Cox regression were used to evaluate the overall survival at 5 years old. Results: In the 148 patients evaluated, the most prevalent nutritional status was overweight/obesity (43.2%) and 27.0% had severe WL. Sixty-seven subjects (45.3%) had NLR ≥ 3 that was associated with the lower OS (P < 0.001). There was a higher OS for overweight/obesepatients (P = 0.002) and a lower among subjects with severe WL (P = 0.009). The NLR ≥3 (HR: 3.639; 95% CI, 1.708-7.771) was an independent poor prognostic factor for OS. Patients without WL (HR: 0.367, 95% CI, 0.141-0.954) and classified as overweight/obesity (HR: 0.260; 95% CI, 0.106-0.639) presented better prognostic. Conclusion: NLR, WL, BMI assessments are promising prognostic indicators in the CRC.
Authors: Ignacio Escobar-Munguía; Ricardo Berea-Baltierra; Ángel Morales-González; Eduardo Madrigal-Santillán; Liliana Anguiano-Robledo; José A Morales-González Journal: Am J Cancer Res Date: 2022-07-15 Impact factor: 5.942
Authors: Maria Hernandez-Ainsa; Raul Velamazan; Angel Lanas; Patricia Carrera-Lasfuentes; Elena Piazuelo Journal: Front Med (Lausanne) Date: 2022-06-20