Ping Wang1, Hua Qiang1, Yan Song2, Ying Dang2, Hui Luan1, Lifei Cao1, Qing Cui1, Gang Tian3. 1. Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. 2. Department of Ultrasound, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. 3. Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, tiangang@xjtu.edu.cn.
Abstract
INTRODUCTION: Obesity is one of the important risk factors of coronary heart disease (CHD). Nonalcoholic fatty liver disease (NAFLD) is always accompanied by obesity. Therefore, this study was designed to elucidate the relationship between NAFLD and CHD in obese and nonobese populations. METHODS: We conducted a cross-sectional study of 454 Chinese patients diagnosed with CHD. Patients were grouped into non-NAFLD + nonobese, non-NAFLD + obese, NAFLD + nonobese, and NAFLD + obese based on the presence or absence of both NAFLD and obesity. RESULTS: The mean Gensini score was significantly higher in patients with fatty liver compared to those without. Logistic regression analysis found that fatty liver, uric acid, and blood glucose levels were risk factors for a high Gensini score. CONCLUSIONS: Irrespective of the presence of obesity, NAFLD is a risk factor for CHD, and the clinical effect of nonobese fatty liver (especially in women) should be carefully considered.
INTRODUCTION:Obesity is one of the important risk factors of coronary heart disease (CHD). Nonalcoholic fatty liver disease (NAFLD) is always accompanied by obesity. Therefore, this study was designed to elucidate the relationship between NAFLD and CHD in obese and nonobese populations. METHODS: We conducted a cross-sectional study of 454 Chinese patients diagnosed with CHD. Patients were grouped into non-NAFLD + nonobese, non-NAFLD + obese, NAFLD + nonobese, and NAFLD + obese based on the presence or absence of both NAFLD and obesity. RESULTS: The mean Gensini score was significantly higher in patients with fatty liver compared to those without. Logistic regression analysis found that fatty liver, uric acid, and blood glucose levels were risk factors for a high Gensini score. CONCLUSIONS: Irrespective of the presence of obesity, NAFLD is a risk factor for CHD, and the clinical effect of nonobese fatty liver (especially in women) should be carefully considered.
Authors: Ashwini Arvind; Jacqueline B Henson; Stephanie A Osganian; Cheryl Nath; Lara M Steinhagen; Zoe N Memel; Arley Donovan; Oluwafemi Balogun; Raymond T Chung; Tracey G Simon; Kathleen E Corey Journal: Hepatol Commun Date: 2021-09-02