Literature DB >> 31665200

Usefulness of Dual Immunohistochemistry Staining in Detection of Hairy Cell Leukemia in Bone Marrow.

Gaurav K Gupta1,2, Xiaoping Sun2, Constance M Yuan3, Maryalice Stetler-Stevenson3, Robert J Kreitman4, Irina Maric2.   

Abstract

OBJECTIVES: We evaluated efficacy of two dual immunohistochemistry (IHC) staining assays in assessing hairy cell leukemia (HCL) involvement in core biopsies and compared the results with concurrently collected flow cytometric data.
METHODS: Overall, 148 patients with HCL (123 male, 25 female; mean age: 59.8 years; range: 25-81 years) had multiparameter flow cytometry performed using CD19, CD20, CD22, CD11c, CD25, CD103, CD123, surface light chains, CD5, and CD23. In parallel, bone marrow IHC was done using PAX5/CD103 and PAX5/tartrate-resistant alkaline phosphatase (TRAP) dual IHC stains.
RESULTS: Overall sensitivity of dual IHC stains was 81.4%, positive predictive value was 100%, and negative predictive value was 81.7%. All IHC-positive cases concurred with flow cytometry data, even when HCL burden was extremely low in the flow cytometry specimens (as low as 0.02% of all lymphoid cells).
CONCLUSIONS: Dual IHC stain is a sensitive tool in detecting HCL, even in cases with minimal disease involvement. © American Society for Clinical Pathology, 2019.

Entities:  

Keywords:  Bone marrow; Flow cytometry; Hairy cell leukemia; Immunohistochemistry

Mesh：

Year:  2020        PMID： 31665200      PMCID： PMC7315001          DOI： 10.1093/ajcp/aqz171

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  15 in total

1.  Minimal residual disease in patients with hairy cell leukemia in complete remission treated with 2-chlorodeoxyadenosine or 2-deoxycoformycin and prediction of early relapse.

Authors:  M S Tallman; D Hakimian; K J Kopecky; S Wheaton; E Wollins; K Foucar; P A Cassileth; T Habermann; M Grever; J M Rowe; L C Peterson
Journal:  Clin Cancer Res       Date:  1999-07       Impact factor: 12.531

2.  Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody.

Authors:  Elizabeth A Morgan; Hongbo Yu; Jack L Pinkus; Geraldine S Pinkus
Journal:  Am J Clin Pathol       Date:  2013-02       Impact factor: 2.493

3.  Monoclonal antibody B-ly7: a sensitive marker for detection of minimal residual disease in hairy cell leukemia.

Authors:  J Thaler; O Dietze; V Faber; R Greil; G Gastl; H Denz; A D Ho; H Huber
Journal:  Leukemia       Date:  1990-03       Impact factor: 11.528

4.  The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia.

Authors:  Hampar Akkaya; Oner Dogan; Mehmet Agan; Guncag Dincol
Journal:  APMIS       Date:  2005-03       Impact factor: 3.205

5.  Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia: usefulness of CD123 and CD103 in the diagnosis of mature B-cell lymphoproliferative disorders.

Authors:  Girish Venkataraman; Christine Aguhar; Robert J Kreitman; Constance M Yuan; Maryalice Stetler-Stevenson
Journal:  Am J Clin Pathol       Date:  2011-10       Impact factor: 2.493

Review 6.  The 2016 revision of the World Health Organization classification of lymphoid neoplasms.

Authors:  Steven H Swerdlow; Elias Campo; Stefano A Pileri; Nancy Lee Harris; Harald Stein; Reiner Siebert; Ranjana Advani; Michele Ghielmini; Gilles A Salles; Andrew D Zelenetz; Elaine S Jaffe
Journal:  Blood       Date:  2016-03-15       Impact factor: 22.113

7.  An assessment of the usefulness of immunohistochemical stains in the diagnosis of hairy cell leukemia.

Authors:  Michael J Sherman; Curtis A Hanson; James D Hoyer
Journal:  Am J Clin Pathol       Date:  2011-09       Impact factor: 2.493

8.  Immunohistochemical Detection of Hairy Cell Leukemia in Paraffin Sections: The Role of Pax5 and CD103 Double Staining to Improve Specificity and Sensitivity.

Authors:  Igor B Rozenvald; Maurice D Richardson; Lenessa Brock; Russell L Maiese
Journal:  Arch Pathol Lab Med       Date:  2017-04-18       Impact factor: 5.534

9.  Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics.

Authors:  Henry Y Dong; James Weisberger; Zach Liu; Sorina Tugulea
Journal:  Am J Clin Pathol       Date:  2009-04       Impact factor: 2.493

10.  Distinguishing hairy cell leukemia variant from hairy cell leukemia: development and validation of diagnostic criteria.

Authors:  Haipeng Shao; Katherine R Calvo; Marlene Grönborg; Prashant R Tembhare; Robert J Kreitman; Maryalice Stetler-Stevenson; Constance M Yuan
Journal:  Leuk Res       Date:  2013-01-22       Impact factor: 3.156
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  4 in total

1.  The Effectiveness of Dual-Staining Immunohistochemistry in the Detection of Mantle Cell Lymphoma in the Bone Marrow.

Authors:  Ifeyinwa E Obiorah; Hao-Wei Wang; David Ma; Eddie Martin; Wyndham H Wilson; Raul Braylan
Journal:  Am J Clin Pathol       Date:  2022-05-04       Impact factor: 5.400

2.  Droplet digital polymerase chain reaction for the assessment of disease burden in hairy cell leukemia.

Authors:  Alessandro Broccoli; Carolina Terragna; Laura Nanni; Marina Martello; Silvia Armuzzi; Claudio Agostinelli; Alice Morigi; Beatrice Casadei; Cinzia Pellegrini; Vittorio Stefoni; Elena Sabattini; Lisa Argnani; Pier Luigi Zinzani
Journal:  Hematol Oncol       Date:  2021-10-15       Impact factor: 4.850

Review 3.  Development of Recombinant Immunotoxins for Hairy Cell Leukemia.

Authors:  Robert J Kreitman; Ira Pastan
Journal:  Biomolecules       Date:  2020-08-03

4.  Concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and hairy cell leukemia: clinical, pathologic and molecular features.

Authors:  Ifeyinwa Emmanuela Obiorah; Ivo M B Francischetti; Hao-Wei Wang; Inhye E Ahn; Weixin Wang; Mark Raffeld; Robert J Kreitman; Adrian Wiestner; Katherine R Calvo
Journal:  Leuk Lymphoma       Date:  2020-08-05
  4 in total

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