Xiao Qing Ma1, Chao Qiang Jiang2, Lin Xu1,3, Wei Sen Zhang2, Feng Zhu2, Ya Li Jin2, G Neil Thomas4, Tai Hing Lam2,3. 1. School of Public Health, Sun Yat-sen University, Guangzhou, China. 2. Guangzhou No.12 Hospital, Guangzhou 510620, China. 3. School of Public Health, The University of Hong Kong, Hong Kong. 4. Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Abstract
BACKGROUND: evidence concerning the relationship between sleep quality and cognitive impairment is limited and inconsistent. OBJECTIVE: to examine the association of sleep quality with memory impairment and poor cognitive function in a large sample of older Chinese. METHODS: 15,246 participants aged 50+ years of the Guangzhou Biobank Cohort Study who attended the second physical examination from 2008 to 2012 were included. Sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), and cognitive performance was assessed using both Delayed Word Recall Test (DWRT) and Mini-Mental State Examination (MMSE). Memory impairment was defined by DWRT score < 4 and poor cognitive function by MMSE score < 25. RESULTS: after adjusting for potential confounders, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poor cognitive function with a dose-response pattern (both P for trend <0.001). The adjusted odds ratio (OR, 95% confidence interval (CI)) for poor cognitive function in those with the sleep efficiency of 75-85%, 65-75% and <65%, versus ≥85%, was 1.31 (1.12-1.53), 1.41 (1.16-1.73) and 1.33 (1.09-1.63), respectively. No association of the global PSQI score with memory impairment or poor cognitive function was found. CONCLUSIONS: in older Chinese people, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poorer cognitive function.
BACKGROUND: evidence concerning the relationship between sleep quality and cognitive impairment is limited and inconsistent. OBJECTIVE: to examine the association of sleep quality with memory impairment and poor cognitive function in a large sample of older Chinese. METHODS: 15,246 participants aged 50+ years of the Guangzhou Biobank Cohort Study who attended the second physical examination from 2008 to 2012 were included. Sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), and cognitive performance was assessed using both Delayed Word Recall Test (DWRT) and Mini-Mental State Examination (MMSE). Memory impairment was defined by DWRT score < 4 and poor cognitive function by MMSE score < 25. RESULTS: after adjusting for potential confounders, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poor cognitive function with a dose-response pattern (both P for trend <0.001). The adjusted odds ratio (OR, 95% confidence interval (CI)) for poor cognitive function in those with the sleep efficiency of 75-85%, 65-75% and <65%, versus ≥85%, was 1.31 (1.12-1.53), 1.41 (1.16-1.73) and 1.33 (1.09-1.63), respectively. No association of the global PSQI score with memory impairment or poor cognitive function was found. CONCLUSIONS: in older Chinese people, lower habitual sleep efficiency was associated with a higher risk of memory impairment and poorer cognitive function.
Authors: Jiao Wang; Wei Sen Zhang; Chao Qiang Jiang; Feng Zhu; Ya Li Jin; Kar Keung Cheng; Tai Hing Lam; Lin Xu Journal: BMC Med Date: 2022-05-02 Impact factor: 11.150